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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Brain estrogens rapidly strengthen auditory encoding and guide song preference in a songbird
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Brain estrogens rapidly strengthen auditory encoding and guide song preference in a songbird

机译:脑雌激素可快速增强听觉编码并指导鸣禽中的歌曲偏好

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摘要

Higher cognitive function depends on accurate detection and processing of subtle features of sensory stimuli. Such precise computations require neural circuits to be modulated over rapid timescales, yet this modulation is poorly understood. Brain-derived steroids (neurosteroids) can act as fast signaling molecules in the vertebrate central nervous system and could therefore modulate sensory processing and guide behavior, but there is no empirical evidence for this possibility. Here we report that acute inhibition of estrogen production within a cortical-like region involved in complex auditory processing disrupts a songbird's ability to behaviorally respond to song stimuli. Identical manipulation of local estrogen levels rapidly changes burst firing of single auditory neurons. This acute estrogen-mediated modulation targets song and not other auditory stimuli, possibly enabling discrimination among species-specific signals. Our results demonstrate a crucial role for neuroestrogen synthesis among vertebrates for enhanced sensory encoding. Cognitive impairments associated with estrogen depletion, including verbal memory loss in humans, may therefore stem from compromised moment-by-moment estrogen actions in higher-order cortical circuits.
机译:更高的认知功能取决于对感觉刺激微妙特征的准确检测和处理。这种精确的计算需要在快速的时间尺度上对神经电路进行调制,但是这种调制的理解却很少。脑源性类固醇(神经类固醇)可以在脊椎动物中枢神经系统中充当快速信号分子,因此可以调节感觉过程并指导行为,但是没有经验证据证明这种可能性。在这里我们报告说,在复杂的听觉处理涉及的皮质样区域内对雌激素产生的急性抑制作用会破坏鸣禽的行为对歌曲刺激做出反应的能力。局部雌激素水平的相同操纵会迅速改变单个听觉神经元的爆发放电。这种急性雌激素介导的调节作用是针对歌曲而不是其他听觉刺激,从而可能区分特定物种的信号。我们的结果证明了脊椎动物中神经雌激素合成对于增强感觉编码至关重要。因此,与雌激素耗竭相关的认知障碍,包括人类的口头记忆力丧失,可能源于高阶皮质回路中瞬间雌激素作用受到损害。

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  • 作者单位

    Departments of Physiological Science Brain Research Institute, University of California, Los Angeles, CA 90095 Ecology and Evolutionary Biology, Brain Research Institute, University of California, Los Angeles, CA 90095 Laboratory of Neuroendocrinology, Brain Research Institute, University of California, Los Angeles, CA 90095;

    Joint Science Department of the Claremont Colleges, W. M. Keck Science Center, Claremont, CA 91711;

    Departments of Physiological Science Brain Research Institute, University of California, Los Angeles, CA 90095 Ecology and Evolutionary Biology, Brain Research Institute, University of California, Los Angeles, CA 90095 Laboratory of Neuroendocrinology, Brain Research Institute, University of California, Los Angeles, CA 90095;

    Departments of Physiological Science Brain Research Institute, University of California, Los Angeles, CA 90095 Ecology and Evolutionary Biology, Brain Research Institute, University of California, Los Angeles, CA 90095 Laboratory of Neuroendocrinology, Brain Research Institute, University of California, Los Angeles, CA 90095;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    birdsong; microdialysis; neurotransmission; nongenomic; sex steroid;

    机译:鸟鸣微透析神经传递非基因组性类固醇;

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