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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Contrasts between adaptive coding and noncoding changes during human evolution
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Contrasts between adaptive coding and noncoding changes during human evolution

机译：人类进化过程中自适应编码和非编码变化之间的对比

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摘要

Changes in non-protein-coding regulatory DNA sequences have been proposed to play distinctive roles in adaptive evolution. We analyzed correlations between gene functions and evidence for positive selection in a common statistical framework across several large surveys of coding and noncoding sequences throughout the human genome. Strong correlations with both classifications in gene ontologies and measurements of gene expression indicate that neural development and function have adapted mainly through noncoding changes. In contrast adaptation via coding changes is dominated by immunity, olfaction, and male reproduction. Genes with highly tissue-specific expression have undergone more adaptive coding changes, suggesting that pleiotropic constraints inhibit such changes in broadly expressed genes. In contrast, adaptive noncoding changes do not exhibit this pattern. Our findings underscore the probable importance of noncoding changes in the evolution of human traits, particularly cognitive traits.
机译：已提出非蛋白质编码调控DNA序列的变化在适应性进化中起独特作用。我们在整个人类基因组中对编码和非编码序列进行的几次大型调查中，在共同的统计框架中分析了基因功能与阳性选择证据之间的相关性。与基因本体论的分类和基因表达的测量之间的强相关性表明，神经发育和功能主要通过非编码变化来适应。相反，通过编码变化的适应主要是免疫力，嗅觉和雄性生殖。具有高度组织特异性表达的基因经历了更多的适应性编码变化，表明多效性约束抑制了广泛表达的基因中的这种变化。相反，自适应非编码更改不会显示此模式。我们的发现强调了非编码变化在人类特质，尤其是认知特质的进化中的重要性。

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