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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons
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Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons

机译：空间学习雕刻成年海马神经元的树突状乔木

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摘要

Neurogenesis in the hippocampus is characterized by the birth of thousand of cells that generate neurons throughout life. The fate of these adult newborn neurons depends on life experiences. In particular, spatial learning promotes the survival and death of new neurons. Whether learning influences the development of the dendritic tree of the surviving neurons (a key parameter for synaptic integration and signal processing) is unknown. Here we show that learning accelerates the maturation of their dendritic trees and their integration into the hippocampal network. We demonstrate that these learning effects on dendritic arbors are homeostatically regulated, persist for several months, and are specific to neurons born during adujthood. Finally, we show that this dendritic shaping depends on the cognitive demand and relies on the activation of NMD A receptors. In the search for the structural changes underlying long-term memory, these findings lead to the conclusion that shaping neo-networks is important in forming spatial memories.
机译：海马神经发生的特征是一生中产生神经元的数千个细胞的诞生。这些成年新生神经元的命运取决于生活经历。特别地，空间学习促进了新神经元的生存和死亡。学习是否影响存活神经元的树突状树的发育（突触整合和信号处理的关键参数）尚不清楚。在这里，我们表明学习促进了树突树的成熟以及它们整合到海马网络中。我们证明对树突状树突的这些学习作用是稳态调节的，持续数月，并且特定于成年期间出生的神经元。最后，我们表明这种树突状形成取决于认知需求，并依赖于NMD A受体的激活。在寻找长期记忆基础的结构变化时，这些发现得出结论，塑造新网络对形成空间记忆很重要。

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  • 作者

    Sophie Tronel; Annabelle Fabre; Vanessa Charrier; Stephane H. R. Oliet; Fred H. Gage; Djoher Nora Abrous;

  • 作者单位

    Institut National de la sante et de la Recherche Medicale, Unite 862, Neurocentre Magendie, Neurogenesis and Pathophysiology Group, 33077 Bordeaux, France Universite de Bordeaux, 33077 Bordeaux, France;

    rnInstitut National de la sante et de la Recherche Medicale, Unite 862, Neurocentre Magendie, Neurogenesis and Pathophysiology Group, 33077 Bordeaux, France Universite de Bordeaux, 33077 Bordeaux, France;

    rnInstitut National de la sante et de la Recherche Medicale, Unite 862, Neurocentre Magendie, Neurogenesis and Pathophysiology Group, 33077 Bordeaux, France Universite de Bordeaux, 33077 Bordeaux, France;

    rnUniversite de Bordeaux, 33077 Bordeaux, France lnstitut de la Sante et de la Recherche Medicale U862, Neurocentre Magendie, Glia-Neuron Interactions Group, 33077 Bordeaux, France;

    rnLaboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037;

    rnInstitut National de la sante et de la Recherche Medicale, Unite 862, Neurocentre Magendie, Neurogenesis and Pathophysiology Group, 33077 Bordeaux, France Universite de Bordeaux, 33077 Bordeaux, France;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    adult neurogenesis; memory; spatial learning; hippocampus; dendrite;

    机译：成人神经发生记忆;空间学习;海马枝晶;

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