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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Imprints of the genetic code in the ribosome
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Imprints of the genetic code in the ribosome

机译：核糖体中遗传密码的印记

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摘要

The establishment of the genetic code remains elusive nearly five decades after the code was elucidated. The stereochemical hypothesis postulates that the code developed from interactions between nucleotides and amino acids, yet supporting evidence in a biological context is lacking. We show here that anticodons are selectively enriched near their respective amino acids in the ribosome, and that such enrichment is significantly correlated with the canonical code over random codes. Ribosomal anticodon-amino acid enrichment further reveals that specific codons were reassigned during code evolution, and that the code evolved through a two-stage transition from ancient amino acids without anticodon interaction to newer additions with anticodon interaction. The ribosome thus serves as a molecular fossil, preserving biological evidence that anticodon-amino acid interactions shaped the evolution of the genetic code.
机译：阐明遗传密码后近五十年，遗传密码的建立仍然遥遥无期。立体化学假说假定该密码是从核苷酸和氨基酸之间的相互作用发展而来的，但缺乏生物学上的证据。我们在这里显示，反密码子在核糖体中的各自氨基酸附近有选择地富集，并且这种富集与随机密码上的规范密码显着相关。核糖体的反密码子氨基酸富集进一步揭示了特定密码子在密码进化过程中被重新分配，并且密码通过从无反密码子相互作用的古老氨基酸到具有反密码子相互作用的新添加物的两阶段过渡而进化。因此，核糖体充当了分子化石，保留了反密码子-氨基酸相互作用影响遗传密码进化的生物学证据。

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