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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Perifornical Urocortin-3 mediates the link between stress-induced anxiety and energy homeostasis
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Perifornical Urocortin-3 mediates the link between stress-induced anxiety and energy homeostasis

机译：周围神经Urocortin-3介导压力诱发的焦虑与能量稳态之间的联系

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摘要

In response to physiological or psychological challenges, the brain activates behavioral and neuroendocrine systems linked to both metabolic and emotional outputs designed to adapt to the demand. However, dysregulation of integration of these physiological responses to challenge can have severe psychological and physiological consequences, and inappropriate regulation, disproportional intensity, or chronic or irreversible activation of the stress response is linked to the etiology and pathophysiology of mood and metabolic disorders. Using a transgenic mouse model and lentiviral approach, we demonstrate the involvement of the. hypothalamic neuropeptide Urocortin-3, a specific ligand for the type-2 corticotro-pin-releasing factor receptor, in modulating septal and hypothalamic nuclei responsible for anxiety-like behaviors and metabolic functions, respectively. These results position Urocortin-3 as a neuro-modulator linking stress-induced anxiety. and energy homeostasis and pave the way toward better understanding of the mechanisms that mediate the reciprocal relationships between stress, mood and metabolic disorders.
机译：响应生理或心理挑战，大脑会激活与代谢和情绪输出相关的行为和神经内分泌系统，这些输出旨在适应需求。然而，对挑战的这些生理反应的整合失调会产生严重的心理和生理后果，并且压力反应的不适当调节，失调强度或慢性或不可逆激活与情绪和代谢紊乱的病因和病理生理有关。使用转基因小鼠模型和慢病毒方法，我们证明了其参与。下丘脑神经肽Urocortin-3是2型皮质激素释放因子受体的特异性配体，分别调节负责焦虑样行为和代谢功能的间隔和下丘脑核。这些结果将Urocortin-3定位为连接应激诱导的焦虑的神经调节剂。和能量稳态，并为更好地理解介导压力，情绪和代谢紊乱之间相互关系的机制铺平了道路。

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