...
【24h】

α-Synuclein gene duplication impairs reward learning

机译:α-突触核蛋白基因重复削弱奖励学习

获取原文
获取原文并翻译 | 示例
           

摘要

α-Synuclein (SNCA) plays an important role in the regulation of dopaminergic neurotransmission and neurodegeneration in Parkinson disease. We investigated reward and punishment learning in asymptomatic carriers of a rare SNCA gene duplication who were healthy siblings of patients with Parkinson disease. Results revealed that healthy SNCA duplication carriers displayed impaired reward and intact punishment learning compared with noncarriers. These results demonstrate that a copy number variation of the SNCA gene is associated with selective impairments on reinforcement learning in asymptomatic carriers without the motor symptoms of Parkinson disease.
机译:α-突触核蛋白(SNCA)在帕金森病的多巴胺能神经传递和神经变性的调节中起重要作用。我们调查了罕见的SNCA基因重复无症状携带者的奖惩行为,这些人是帕金森氏病患者的健康兄弟姐妹。结果显示,与非携带者相比,健康的SNCA复制携带者显示出受损的奖赏和完整的惩罚学习。这些结果表明,SNCA基因的拷贝数变异与无症状携带者无帕金森病运动症状的强化学习中的选择性损伤有关。

著录项

  • 来源
  • 作者单位

    Department of Physiology, Faculty of Medicine, University of Szeged, 6720, Szeged, Hungary National Psychiatry Center, Semmelweis University, 1083 Budapest, Hungary;

    rnCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102;

    rnStress and Motivated Behavior Institute, Veterans Affairs Medical Center, New Jersey Health Care System, East Orange, NJ 07018 Department of Psychology, Rutgers University, Newark, NJ 07102;

    rnDepartment of Physiology, Faculty of Medicine, University of Szeged, 6720, Szeged, Hungary;

    rnCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    parkinson disease; reinforcement learning; dopamine; basal ganglia;

    机译:帕金森综合症;强化学习;多巴胺基底神经节;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号