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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Fold-change detection and scalar symmetry of sensory input fields
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Fold-change detection and scalar symmetry of sensory input fields

机译：感觉输入场的倍数变化检测和标量对称

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摘要

Recent studies suggest that certain cellular sensory systems display fold-change detection (FCD): a response whose entire shape, including amplitude and duration, depends only on fold changes in input and not on absolute levels. Thus, a step change in input from, for example, level 1 to 2 gives precisely the same dynamical output as a step from level 2 to 4, because the steps have the same fold change. We ask what the benefit of FCD is and show that FCD is necessary and sufficient for sensory search to be independent of multiplying the input field by a scalar. Thus, the FCD search pattern depends only on the spatial profile of the input and not on its amplitude. Such scalar symmetry occurs in a wide range of sensory inputs, such as source strength multiplying diffusing/converting chemical fields sensed in chemotaxis, ambient light multiplying the contrast field in vision, and protein concentrations multiplying the output in cellular signaling systems. Furthermore, we show that FCD entails two features found across sensory systems, exact adaptation and Weber's law, but that these two features are not sufficient for FCD. Finally, we present a wide class of mechanisms that have FCD, including certain nonlinear feedback and feed-forward loops. We find that bacterial chemotaxis displays feedback within the present class and hence, is expected to show FCD. This can explain experiments in which chemotaxis searches are insensitive to attractant source levels. This study, thus, suggests a connection between properties of biological sensory systems and scalar symmetry stemming from physical properties of their input fields.
机译：最近的研究表明，某些细胞感觉系统显示出倍数变化检测（FCD）：这种响应的整个形状（包括振幅和持续时间）仅取决于输入倍数变化，而不取决于绝对水平。因此，从例如级别1到2的输入的阶跃变化给出与从级别2到4的阶跃精确地相同的动态输出，因为阶跃具有相同的倍数变化。我们问FCD的好处是什么，并证明FCD对于将独立于输入字段乘以标量的感官搜索是必要和充分的。因此，FCD搜索模式仅取决于输入的空间轮廓，而不取决于其幅度。这种标量对称性发生在广泛的感觉输入中，例如源强度乘以趋化性感测的扩散/转换化学场，环境光乘以视觉中的对比度场，以及蛋白质浓度乘以细胞信号系统的输出。此外，我们证明了FCD具有在整个感觉系统中发现的两个特征，即精确适应和韦伯定律，但是这两个特征对于FCD而言还不够。最后，我们介绍了具有FCD的各种机制，包括某些非线性反馈和前馈回路。我们发现细菌趋化性显示当前类内的反馈，因此有望显示FCD。这可以解释其中趋化性搜索对引诱源水平不敏感的实验。因此，这项研究提出了生物感官系统的特性与源于其输入场物理特性的标量对称性之间的联系。

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  • 作者

    Oren Shoval; Lea Goentoro; Yuval Hart; Avi Mayo; Eduardo Sontag; Uri Alon;

  • 作者单位

    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel;

    rnDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115;

    rnDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel;

    rnDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel;

    rnDepartment of Mathematics, Rutgers University, Piscataway, NJ 08854;

    rnDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    adaptation; sensory response; spatial search;

    机译：适应;感觉反应;空间搜索;

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