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首页> 外文期刊>Neuron >Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex
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Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex

机译：Ctip1控制发育中的新皮层的感觉区识别的获取和感觉输入场的建立

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摘要

While transcriptional controls over the size and relative position of cortical areas have been identified, less is known about regulators that direct acquisition of area-specific characteristics. Here, we report that the transcription factor Ctip1 functions in primary sensory areas to repress motor and activate sensory programs of gene expression, enabling establishment of sharp molecular boundaries defining functional areas. In Ctip1 mutants, abnormal gene expression leads to aberrantly motorized corticocortical and corticofugal output connectivity. Ctip1 critically regulates differentiation of layer IV neurons, and selective loss of Ctip1 in cortex deprives thalamocortical axons of their receptive "sensory field'' in layer IV, which normally provides a tangentially and radially defined compartment of dedicated synaptic territory. Therefore, although thalamocortical axons invade appropriate cortical regions, they are unable to organize into properly configured sensory maps. Together, these data identify Ctip1 as a critical control over sensory area development.
机译：虽然已经确定了对皮层区域的大小和相对位置的转录控制，但是对直接获取区域特定特征的调节子了解较少。在这里，我们报告转录因子Ctip1在主要的感觉区域发挥功能，以抑制运动并激活基因表达的感觉程序，从而使定义功能区域的尖锐分子边界得以建立。在Ctip1突变体中，异常基因表达会导致异常的皮质皮质和皮质性果蝇输出连接性。 Ctip1严格调节IV层神经元的分化，皮质中Ctip1的选择性丧失使丘脑皮层轴突失去了IV层的“感觉场”，该区域通常在切向和径向上限定了专门的突触区域。侵入适当的皮质区域，它们无法组织成正确配置的感觉图，这些数据一起将Ctip1识别为对感觉区域发育的关键控制。

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