• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Biomimetic cilia arrays generate simultaneous pumping and mixing regimes
【24h】

Biomimetic cilia arrays generate simultaneous pumping and mixing regimes

机译：仿生纤毛阵列同时产生泵送和混合状态

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Living systems employ cilia to control and to sense the flow of fluids for many purposes, such as pumping, locomotion, feeding, and tissue morphogenesis. Beyond their use in biology, functional arrays of artificial cilia have been envisaged as a potential biomimetic strategy for inducing fluid flow and mixing in lab-on-a-chip devices. Here we report on fluid transport produced by magnetically actuated arrays of biomimetic cilia whose size approaches that of their biological counterparts, a scale at which advection and diffusion compete to determine mass transport. Our biomimetic cilia recreate the beat shape of embryonic nodal cilia, simultaneously generating two sharply segregated regimes of fluid flow: Above the cilia tips their motion causes directed, long-range fluid transport, whereas below the tips we show that the cilia beat generates an enhanced diffusivity capable of producing increased mixing rates. These two distinct types of flow occur simultaneously and are separated in space by less than 5 urn, approximately 20% of the biomimetic cilium length. While this suggests that our system may have applications as a versatile microf luidics device, we also focus on the biological implications of our findings. Our statistical analysis of particle transport identifying an enhanced diffusion regime provides novel evidence for the existence of mixing in ciliated systems, and we demonstrate that the directed transport regime is Poiseuille-Couette flow, the first analytical model consistent with biological measurements of fluid flow in the embryonic node.
机译：生命系统采用纤毛来控制和感知流体的流动，以实现多种目的，例如泵送，运动，进食和组织形态发生。除了在生物学中的用途外，人造纤毛的功能性阵列还被认为是一种潜在的仿生策略，用于在芯片实验室设备中诱导流体流动和混合。在这里，我们报告了由仿生纤毛的磁致动阵列产生的流体传输，其大小接近其生物学对应物的大小，对流和扩散竞争确定质量传输的尺度。我们的仿生纤毛能重现胚胎节状纤毛的搏动形状，同时产生两种截然不同的流体流动状态：纤毛上方的运动会导致定向的远距离流体传输，而纤毛下方的运动表明纤毛的搏动会增强扩散率能够提高混合速度。这两种不同类型的流动同时发生，并且在空间上的间隔小于5，约为仿生纤毛长度的20％。虽然这表明我们的系统可能作为多功能微流体装置应用，但我们也关注发现的生物学意义。我们对粒子传输的统计分析确定了增强的扩散机制，为纤毛系统中混合的存在提供了新的证据，并且我们证明了定向传输机制是Poiseuille-Couette流，这是第一个与生物学测量流体流动一致的分析模型。胚胎结。

著录项

  • 来源
  • 作者

    A. R. Shields; B. L. Fiser; B. A. Evans; M. R. Falvo; S. Washburn; R. Superfine;

  • 作者单位

    The Virtual Lung Project, Department of Physics and Astronomy, University of North Carolina, Chapel Hill, NC 27599;

    rnThe Virtual Lung Project, Department of Physics and Astronomy, University of North Carolina, Chapel Hill, NC 27599;

    rnDepartment of Physics, Elon University, Elon, NC 27244;

    rnThe Virtual Lung Project, Department of Physics and Astronomy, University of North Carolina, Chapel Hill, NC 27599 Curriculum of Applied Science and Engineering, University of North Carolina, Chapel Hill, NC 27599;

    rnThe Virtual Lung Project, Department of Physics and Astronomy, University of North Carolina, Chapel Hill, NC 27599 Curriculum of Applied Science and Engineering, University of North Carolina, Chapel Hill, NC 27599;

    rnThe Virtual Lung Project, Department of Physics and Astronomy, University of North Carolina, Chapel Hill, NC 27599 Curriculum of Applied Science and Engineering, University of North Carolina, Chapel Hill, NC 27599;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    biomimetics; embryonic nodal cilia; hydrodynamics; low reynold's number;

    机译：仿生;胚胎结纤毛;流体力学雷诺数低;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号