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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation
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Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation

机译：内源性大麻素信号传导指导滋养层细胞谱系分化和胎盘形成

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摘要

In most mammals, placentation is critical for fetal development and pregnancy success. Exposure to marijuana during pregnancy has adverse effects, but whether the placenta is a target of cannabinoid/endocannabinoid signaling is not known. Using mice as a model system, we found that the endocannabinoid system is present in the ectoplacental cone and spongiotrophoblast cells. We also observed that aberrant endocannabinoid signaling confers premature trophoblast stem cell differentiation, and defective trophoblast development and invasion. These defects are reflected in retarded fetal development and compromised pregnancy outcome. Because the endocannabinoid system is conserved in mice and humans, our study suggests that endocannabinoid signaling is critical to placentation and pregnancy success in humans and implicates its potential significance in stem cell biology.
机译：在大多数哺乳动物中，胎盘对于胎儿发育和妊娠成功至关重要。怀孕期间接触大麻会产生不利影响，但是尚不清楚胎盘是否是大麻素/内源性大麻素信号传导的靶标。使用小鼠作为模型系统，我们发现内胚层系统存在于外胎盘锥体和海绵滋养细胞中。我们还观察到异常的内源性大麻素信号传递赋予了滋养层干细胞过早分化，以及滋养层发育和侵袭缺陷。这些缺陷反映在胎儿发育迟缓和妊娠结局受损。因为内源性大麻素系统在小鼠和人类中都是保守的，所以我们的研究表明内源性大麻素信号传导对人类胎盘发育和妊娠成功至关重要，并暗示了其在干细胞生物学中的潜在意义。

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  • 作者

    Xiaofei Sun; Huirong Xie; Jie Yang; Haibin Wang; Heather B. Bradshaw; Sudhansu K. Dey;

  • 作者单位

    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;

    rnDivision of Reproductive Sciences, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;

    rnState Key Laboratory of Reproductive Biology, lnstitute of Zoology, Chinese Academy of Science, Beijing 100101, China;

    rnState Key Laboratory of Reproductive Biology, lnstitute of Zoology, Chinese Academy of Science, Beijing 100101, China;

    rnDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405;

    rnDivision of Reproductive Sciences, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    CNR1; fatty acid amide hydrolase; placenta; stem cell;

    机译：CNR1;脂肪酸酰胺水解酶;胎盘;干细胞;

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