...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions
【24h】

Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions

机译：天然杀伤细胞通过调节缺氧诱导因子依赖的滋养细胞谱系决定，直接指导血chochantar胎盘

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Natural killer (NK) cells are recruited into the uterine stroma during establishment of the- hemochorial placenta and are proposed regulators of uterine spiral artery remodeling. Failures in uterine spiral artery remodeling, are linked to diseases of pregnancy. This prompted an investigation of the involvement of NK cells in placentation. NK cell depletion decreased the delivery of proangio-genic factors and delayed uterine spiral artery development, leading to decreased oxygen tension at the placentation site, stabilized hypoxia-inducible factor 1A protein, and redirected trophoblast differentiation to an invasive phenotype. Trophoblast cells replaced the endothelium of uterine spiral arteries extending the depth of the placental vascular bed and accelerating vessel remodeling. Hypoxia-regulated trophoblast lineage decisions, including expansion of invasive trophoblast, could be reproduced in vitro by using rat trophoblast stem cells and were dependent on hypoxia-inducible factor signaling. We conclude that NK cells guide hemochorial placentation through controlling a hypoxia-sensitive adaptive reflex regulating trophoblast lineage decisions.
机译：天然杀手（NK）细胞在建立含血泡的胎盘过程中被募集到子宫基质中，并被提议作为子宫螺旋动脉重塑的调节剂。子宫螺旋动脉重塑失败与妊娠疾病有关。这促使了对NK细胞参与胎盘的研究。 NK细胞的消耗减少了促血管生成因子的传递并延缓了子宫螺旋动脉的发育，从而导致胎盘部位的氧张力降低，稳定了缺氧诱导因子1A蛋白，并使滋养层细胞的分化重新定向到侵袭性表型。滋养层细胞取代了子宫螺旋动脉的内皮，扩大了胎盘血管床的深度并加速了血管的重塑。缺氧调节的滋养细胞谱系决定，包括侵袭性滋养细胞的扩增，可以通过使用大鼠滋养细胞干细胞在体外复制，并且依赖于缺氧诱导因子信号传导。我们得出的结论是，NK细胞通过控制缺氧敏感的自适应反射调节滋养细胞谱系决定来指导血细胞胎盘植入。

著录项

  • 来源
  • 作者

    Damayanti Chakraborty; M. A. Karim Rumi; Toshihiro Konno; Michael J. Soares;

  • 作者单位

    Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160;

    Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160;

    Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160,Laboratory of Animal Breeding, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo 113-8657 Japan;

    Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号