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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Mammalian skin could serve as a reservoir for malarial parasites
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Mammalian skin could serve as a reservoir for malarial parasites

机译：哺乳动物的皮肤可以作为疟疾寄生虫的宿主

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摘要

The malarial parasite Plasmodium thrives in mammalian hosts by multiplying within circulating red blood cells. The mature, blood-infecting stage of the parasite life cycle, called merozoite, arises in host liver cells from another stage, called sporozoite, injected into the skin throughrnmosquito bites. Since 1948, when researchers demonstrated that sporozoites transform into merozoites in liver cells, it has been widely held that liver cells are the only site for parasite maturation in mammals. By using confocal microscopy, Pascale Gueirard et al. (pp.18640-18645) studied the fate of genetically engineered, fluorescent, rodent-infecting sporozoites introduced into the ear skin of mice by microinjection or through Anopheles mosquito bites.
机译：疟原虫疟原虫通过在循环红细胞内繁殖而在哺乳动物宿主中壮成长。寄生虫生命周期中成熟的，感染血液的阶段称为裂殖子，发生在宿主肝细胞中，是通过蚊子叮咬注入皮肤的另一阶段，即子孢子。自1948年以来，当研究人员证明子孢子在肝细胞中转化为裂殖子时，人们普遍认为肝细胞是哺乳动物中寄生虫成熟的唯一场所。通过使用共聚焦显微镜，Pascale Gueirard等人。 （pp.18640-18645）研究了通过显微注射或通过按蚊按蚊叮咬引入小鼠耳朵皮肤的经基因工程处理的，荧光的，啮齿类动物感染的子孢子的命运。

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