...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The tryptophan photoproduct 6-formylindolo[3,2-b] carbazole helps genes jump
【24h】

The tryptophan photoproduct 6-formylindolo[3,2-b] carbazole helps genes jump

机译：色氨酸光产物6-甲酰基吲哚并[3,2-b]咔唑有助于基因跳跃

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In their mechanistic examination of the role of the aryl hydrocarbon receptor (AHR, also known as the dioxin receptor) in genome shuffling, Okudaira et al. (1) chose to use 6-formylindolo[3,2-b]carbazole (FICZ), a candidate endogenous agonist of this receptor, instead of the more commonly used anthropogenic agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). FICZ was discovered serendipitously when the amino acid L-tryptophan was used to absorb UV B radiation and thereby act as a photosensitizer in experiments designed to produce unique agonists of AHR for quantitative structure-activity relationship analyses (2). On the basis of its formation by photolysis of tryptophan with both visible and UV light, its formation in cells exposed to UV light, and its ability to activate the AHR transiently at concentrations of a few pico-molar, FICZ has been proposed to be an endogenous signaling molecule that mediates biological responses to light (ref. 3 and references therein).
机译：Okudaira等人在对芳烃受体（AHR，也称为二恶英受体）在基因组改组中的作用进行机理研究时。 （1）选择使用6-甲酰基吲哚并[3,2-b]咔唑（FICZ）（该受体的候选内源性激动剂）来代替更常用的人为激动剂2,3,7,8-四氯二苯并-对二恶英（TCDD）。当使用氨基酸L-色氨酸吸收UV B辐射并由此在设计用于产生AHR独特激动剂以进行定量结构-活性关系分析的实验中充当光敏剂时，偶然发现了FICZ（2）。基于通过色氨酸在可见光和紫外光下的光分解形成色氨酸，在暴露于紫外线的细胞中形成色氨酸以及在几皮摩尔浓度下瞬时激活AHR的能力，FICZ被认为是一种介导对光的生物响应的内源性信号分子（参考文献3和其中的参考文献）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号