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Role of the hippocampus in remembering the past and imagining the future

机译:海马在回忆过去和想象未来中的作用

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摘要

It has been proposed that a core network of brain regions, including the hippocampus, supports both past remembering and future imagining. We investigated the importance of the hippocampus for these functions. Five patients with bilateral hippocampal damage and one patient with large medial temporal lobe lesions were tested for their ability to recount autobiographical episodes from the remote past, the recent past, and to imagine plausible episodes in the near future. The patients with hippocampal damage had intact remote autobiographical memory, modestly impaired recent mem ory, and an intact ability to imagine the future. The patient with large medial temporal lobe lesions had intact remote memory, markedly impaired recent memory, and also had an intact ability to imagine the future. The findings suggest that the capacity for imagining the future, like the capacity for remembering the remote past, is independent of the hippocampus.
机译:已经提出,包括海马在内的大脑区域的核心网络支持过去的记忆和未来的想象。我们调查了海马对这些功能的重要性。测试了5名双侧海马损伤患者和1名内侧颞叶病变较大患者的自传历史,近期历史以及近期可能发生的事件的能力。有海马损伤的患者具有完整的远程自传体记忆,适度受损的近期记忆以及完整的想象未来的能力。颞叶内侧病变较大的患者的远距离记忆完整,近期记忆明显受损,并且具有完整的想象未来的能力。这些发现表明,想象未来的能力,例如记住遥远过去的能力,与海马无关。

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  • 作者单位

    Veterans Affairs San Diego Healthcare System, San Diego, CA 92161 Departments of Psychiatry,University of California at San Diego, La Jolla, CA 92093 Departments of Neurosciences,University of California at San Diego, La Jolla, CA 92093 Departments of Psychology, University of California at San Diego, La Jolla, CA 92093;

    rnVeterans Affairs San Diego Healthcare System, San Diego, CA 92161;

    rnDepartments of Psychiatry,University of California at San Diego, La Jolla, CA 92093;

    rnDepartments of Psychiatry,University of California at San Diego, La Jolla, CA 92093;

    rnDepartment of Psychology and Neuroscience Center, Brigham Young University, Provo, UT 84602 Pulmonary and Critical Care Division, Department of Medicine, Intermountain Medical Center, Murray, UT 84143;

    rnDepartments of Psychiatry,University of California at San Diego, La Jolla, CA 92093;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    episodic memory; semantic memory; medial temporal lobe; remote memory; amnesia;

    机译:情景记忆语义记忆;颞中叶远程内存;健忘症;

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