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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Hierarchical order of coexisting pre- and postsynaptic forms of long-term potentiation at synapses in amygdala
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Hierarchical order of coexisting pre- and postsynaptic forms of long-term potentiation at synapses in amygdala

机译：杏仁核突触中长期增强的突触前和突触后形式共存的层次顺序

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摘要

Synaptic rules that may determine the interaction between coex isting forms of long-term potentiation (LTP) at glutamatergic cen tral synapses remain unknown. Here, we show that two mecha nistically distinct forms of LTP could be induced in thalamic input to the lateral nucleus of the amygdala (LA) with an identical pre synaptic stimulation protocol, depending on the level of post synaptic membrane polarization. One form of LTP, resulting from pairing of postsynaptic depolarization and low-frequency presyn aptic stimulation, was both induced and expressed postsynaptically ("post-LTP"). The same stimulation in the absence of postsynaptic depolarization led to LTP, which was induced and expressed pre synaptically ("pre-LTP"). The inducibility of coexisting pre- and postsynaptic forms of LTP at synapses in thalamic input followed a well-defined hierarchical order, such that pre-LTP was suppressed when post-LTP was induced. This interaction was mediated by ac tivation of cannabinoid type 1 receptors by endogenous cannabi noids released in the lateral nucleus of the amygdala in response to activation of the type 1 metabotropic glutamate receptor. These results suggest a previously unknown mechanism by which the hierarchy of coexisting forms of long-term synaptic plasticity in the neural circuits of learned fear could be established, possibly reflecting the hierarchy of memories for the previously experi enced fearful events according to their aversiveness level.
机译：可能确定在谷氨酸能中央突触的共增强形式的长期增强（LTP）之间的相互作用的突触规则仍然未知。在这里，我们显示，根据相同的突触后膜极化水平，在丘脑输入到杏仁核（LA）外侧核的丘脑输入中可以诱导LTP的两种机械上不同的形式。 LTP的一种形式，是由突触后去极化和低频突触前突触刺激配对产生的，并在突触后被诱导和表达（“ LTP后”）。在没有突触后去极化的情况下，相同的刺激导致LTP，其被突触诱导并突触表达（“ LTP之前”）。在丘脑输入突触中，LTP的突触前和突触后形式共存的诱导性遵循明确定义的等级顺序，从而在诱导LTP后时抑制了LTP前。这种相互作用是由响应于1型代谢型谷氨酸受体激活而在杏仁核的侧核中释放的内源性大麻素激活大麻素1型受体的激活介导的。这些结果表明，可以建立以前未知的机制，通过该机制可以建立学习恐惧的神经回路中长期存在的突触可塑性的共存形式的层次结构，这可能反映了根据先前经历过的恐惧事件的厌恶程度而记忆的层次结构。

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    Ryong-Moon Shin; Keith Tully; Yan Li; Jun-Hyeong Cho; Makoto Higuchi; Tetsuya Suhara; Vadim Y. Bolshakov;

  • 作者单位

    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263-8555, Japan;

    rnDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478;

    rnDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478;

    rnDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478;

    rnMolecular Imaging Center, National Institute of Radiological Sciences, Chiba 263-8555, Japan;

    rnMolecular Imaging Center, National Institute of Radiological Sciences, Chiba 263-8555, Japan;

    rnDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    synaptic transmission; glutamate; plasticity; endocannabinoids;

    机译：突触传递谷氨酸可塑性;内源性大麻素;

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