Priori disease susceptibility is affected by β-structure folding propensity and local side-chain interactions in PrP

著录项

• 来源
  《Proceedings of the National Academy of Sciences of the United States of America》 |2010年第46期|p.19808-19813|共6页
• 作者

  M. Qasim Khan; Braden Sweeting; Vikram Khipple Mulligan; Pharhad Eli Arslan; Neil R. Cashman; Emil F. Pai; Avijit Chakrabartty;

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• 作者单位

  Campbell Family Institute for Cancer Research, Ontario Cancer Institute/University Health Network, Department of Biochemistry, University of Toronto, Toronto Medical Discovery Tower 4-307, 101 College Street, Toronto, ON, Canada M5G 1L7;

  Campbell Family Institute for Cancer Research, Ontario Cancer Institute/University Health Network, Department of Medical Biophysics, University of Toronto, Toronto Medical Discovery Tower 4-305, 101 College Street, Toronto, ON, Canada M5G 1L7;

  Campbell Family Institute for Cancer Research, Ontario Cancer Institute/University Health Network, Department of Biochemistry, University of Toronto, Toronto Medical Discovery Tower 4-307, 101 College Street, Toronto, ON, Canada M5G 1L7;

  Campbell Family Institute for Cancer Research, Ontario Cancer Institute/University Health Network, Department of Medical Biophysics, University of Toronto, Toronto Medical Discovery Tower 4-305, 101 College Street, Toronto, ON, Canada M5G 1L7;

  Brain Research Centre, Division of Neurology, Department of Medicine, University of British Columbia and Vancouver Coastal Health, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5;

  Campbell Family Institute for Cancer Research, Ontario Cancer Institute/University Health Network, Department of Biochemistry, University of Toronto, Toronto Medical Discovery Tower 4-307, 101 College Street, Toronto, ON, Canada M5G 1L7,Campbell Family Institute for Cancer Research, Ontario Cancer Institute/University Health Network, Department of Medical Biophysics, University of Toronto, Toronto Medical Discovery Tower 4-305, 101 College Street, Toronto, ON, Canada M5G 1L7,Campbell Family Institute for Cancer Research, Ontario Cancer Institute/University Health Network, Department of Molecular Genetics, University of Toronto, Toronto Medical Discovery Tower 5-358, 101 College Street, Toronto, ON, Canada M5G 1L7;

  Campbell Family Institute for Cancer Research, Ontario Cancer Institute/University Health Network, Department of Biochemistry, University of Toronto, Toronto Medical Discovery Tower 4-307, 101 College Street, Toronto, ON, Canada M5G 1L7,Campbell Family Institute for Cancer Research, Ontario Cancer Institute/University Health Network, Department of Medical Biophysics, University of Toronto, Toronto Medical Discovery Tower 4-305, 101 College Street, Toronto, ON, Canada M5G 1L7;

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• 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
• 原文格式 PDF
• 正文语种 eng
• 中图分类
• 关键词

  protein misfolding; x-ray crystallography; creutzfeldt-jakob disease; bovine spongiform encephalopathy; folding intermediates;

  机译：蛋白质错折叠;X射线晶体学克雅氏病牛海绵状脑病;折叠中间体;