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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection
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Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection

机译：体细胞多样化凝集素在无脊椎动物对寄生虫感染的抵抗中的作用

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摘要

Invertebrates lack adaptive immune systems homologous to those of vertebrates, yet it is becoming increasingly clear that they can produce diversified antigen recognition molecules. We have previously noted that the snail Biomphalaria glabrata produces a secreted lectin, fibrinogen-related protein 3 (FREP3), unusual among invertebrate defense molecules because it is somatically diversified by gene conversion and point mutation. Here we implicate FREP3 in playing a central role in resistance to a major group of snail pathogens, digenetic trematodes. FREP3 is up-regulated in three models of resistance of B. glabrata to infection with Schis-tosoma mansoni or Echinostoma paraensei, and functions as an opsohin favoring phagocytosis by hemocytes. Knock-down of FREP3 in resistant snails using siRNA-mediated interference resulted in increased susceptibility to E. paraensei. providing a direct link between a gastropod immune molecule and resistance to trematodes. FREP3 up-regulation is also associated with heightened responsiveness following priming with attenuated digenetic trematodes (acquired resistance) in this model invertebrate immune system.
机译：无脊椎动物缺乏与脊椎动物同源的适应性免疫系统，但是越来越清楚的是，它们可以产生多种抗原识别分子。我们之前已经注意到，蜗牛glabrata产生一种分泌的凝集素，纤维蛋白原相关蛋白3（FREP3），在无脊椎动物防御分子中并不常见，因为它通过基因转换和点突变在体细胞上多样化。在这里，我们暗示FREP3在抵抗主要的蜗牛病原体，双基因吸虫中发挥重要作用。 FREP3在三种对光滑芽孢杆菌对曼氏志贺氏菌或副猪棘皮虫感染的抗性模型中上调，并起卵磷脂的作用，促进血细胞吞噬。使用siRNA介导的干扰在抗性蜗牛中敲除FREP3导致对副肠埃希氏菌的敏感性增加。提供了腹足动物免疫分子和对吸虫的抗性之间的直接联系。在该模型无脊椎动物免疫系统中，用减毒的双基因吸虫（获得性耐药）启动后，FREP3的上调也与反应性增强有关。

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  • 作者

    Patrick C. Hanington; Michelle A. Forys; Jerry W. Dragoo; Si-Ming Zhang; Coen M. Adema; Eric S. Loker;

  • 作者单位

    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131;

    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131;

    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131;

    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131;

    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131;

    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    host-parasite interactions; evolution; immunology; parasitology; schistosomiasis;

    机译：宿主-寄生虫相互作用;演化;免疫学寄生虫学血吸虫病;

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