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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Type II protein arginine methyltransferase 5 (PRMT5) is required for circadian period determination in Arabidopsis thaliana
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Type II protein arginine methyltransferase 5 (PRMT5) is required for circadian period determination in Arabidopsis thaliana

机译：拟南芥的昼夜节律测定需要II型蛋白精氨酸甲基转移酶5（PRMT5）

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摘要

Posttranslational modification is an important element in circadian clock function from cyanobacteria through plants and mammals. For example, a number of key clock components are phosphory-lated and thereby marked for subsequent ubiquitination and degradation. Through forward genetic analysis we demonstrate that protein arginine methyltransferase 5 (PRMTS; At4g31120) is a critical determinant of circadian period in Arabidopsis. PRMTS is coregulated with a set of 1,253 genes that shows alterations in phase of expression in response to entrainment to thermocycles versus photocycles in constant temperature. PRMTS encodes a type II protein arginine methyltransferase that catalyzes the symmetric dimethylation of arginine residues (Rsme2). Rsme2 modification has been observed in many taxa, and targets include histories, components of the transcription complex, and components of the spli-ceosome. Neither arginine methylation nor PRMT5 has been implicated previously in circadian clock function, but the period lengthening associated with mutational disruption of prmt5 indicates that Rsme2 is a decoration important for the Arabidopsis clock and possibly for clocks in general.
机译：翻译后修饰是从蓝细菌到植物和哺乳动物的昼夜节律功能的重要元素。例如，许多关键时钟成分被磷酸化，从而被标记用于随后的泛素化和降解。通过正向遗传分析，我们证明了精氨酸甲基转移酶5（PRMTS; At4g31120）是拟南芥昼夜节律的关键决定因素。 PRMTS与一组1,253个基因共调节，这些基因显示了在固定温度下响应于热循环与光循环的夹带，表达阶段发生了变化。 PRMTS编码II型蛋白精氨酸甲基转移酶，可催化精氨酸残基（Rsme2）的对称二甲基化。在许多类群中已经观察到Rsme2修饰，其靶标包括历史，转录复合物的成分和裂体-脂质体的成分。既未涉及精氨酸甲基化也未涉及PRMT5的昼夜节律功能，但与prmt5突变破坏有关的周期延长表明Rsme2是对拟南芥属时钟乃至整个时钟重要的装饰。

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  • 作者

    Sunghyun Hong; Hae-Ryong Song; Kerry Lutz; Randall A. Kerstetter; Todd P. Michael; C. Robertson McClung;

  • 作者单位

    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755,Division of Molecular Life Sciences, Pohang University of Science and Technology, Hyoja-dong, Pohang, Kyungbuk 790-784, Republic of Korea;

    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755,Global Research Laboratory for Floral Regulatory Signaling, School of .Biological Sciences, Seoul National University, Seoul 151-747, Republic of Korea;

    The Waksman Institute of Microbiology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854;

    The Waksman Institute of Microbiology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854;

    The Waksman Institute of Microbiology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854;

    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    circadian rhythms; circadian clock; luciferase;

    机译：昼夜节律;生物钟萤光素酶;

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