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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129
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Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129

机译：使用超极化Xenon-129同时进行人肺通气分布和气体吸收的磁共振成像

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摘要

Despite a myriad of technical advances in medical imaging, as well as the growing need to address the global impart of pulmonary diseases, such as asthma and chronic obstructive pulmonary disease, on health and "quality of life, it remains challenging to obtain in vivo regional depiction and quantification of the most basic physiological functions of the lung-gas delivery to the airspaces and gas uptake by the lung parenchyma and blood-in a manner suitable for routine application in humans. We report a method based on MRI of hyperpolarized xenon-129 that permits simultaneous observation of the 3D distributions of ventilation (gas delivery) and gas uptake, as well as quantification of regional gas uptake based on the associated ventilation. Subjects with lung disease showed variations in gas uptake that differed from those in ventilation in many regions, suggesting that gas uptake as measured by this technique reflects such features as underlying pathological alterations of lung tissue or of local blood flow. Furthermore, the ratio of the signal associated with gas uptake to that associated with ventilation was substantially altered in subjects with lung disease compared with healthy subjects. This MRI-based method provides a way to quantify relationships among gas delivery, exchange, and transport, and appears to have significant potential to provide more insight into lung disease.
机译：尽管医学成像技术取得了无数的技术进步，并且解决健康和“生活质量”对解决全球性肺疾病（例如哮喘和慢性阻塞性肺疾病）的需求日益增长，但获得体内区域性肝癌仍具有挑战性肺气的最基本生理功能的描述和定量以及肺实质和血液对气体的吸收，以适合人类常规应用的方式进行报道，我们报告了一种基于MRI的超极化氙129方法可以同时观察通气量（气体输送）和气体吸收量的3D分布，并根据相关的通气量定量区域性气体吸收量。肺部疾病患者的气体吸收量变化与许多地区的通气量不同，表明用这种技术测量的气体吸收反映了诸如肺组织潜在病理改变等特征或局部血流。此外，与健康受试者相比，患有肺部疾病的受试者与气体吸收有关的信号与与通气有关的信号的比率显着改变。这种基于MRI的方法提供了一种量化气体输送，交换和传输之间关系的方法，并且似乎具有巨大的潜力，可提供对肺部疾病的更多见解。

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  • 作者

    John P. Mugler III; Talissa A. Altes; lulian C. Ruset; Isabel M. Dregely; Jaime F. Mata; G. Wilson Miller; Stephen Ketel; Jeffrey Ketel; F. William Hersman; Kai Ruppert;

  • 作者单位

    Center for In Vivo Hyperpolarized Gas MR Imaging, Department of Radiology, University of Virginia, Charlottesville, VA 22908;

    Center for In Vivo Hyperpolarized Gas MR Imaging, Department of Radiology, University of Virginia, Charlottesville, VA 22908;

    Xemed LLC, Durham,NH 03824,Department of Physics, University of New Hampshire, Durham, NH 03824;

    Department of Physics, University of New Hampshire, Durham, NH 03824;

    Center for In Vivo Hyperpolarized Gas MR Imaging, Department of Radiology, University of Virginia, Charlottesville, VA 22908;

    Center for In Vivo Hyperpolarized Gas MR Imaging, Department of Radiology, University of Virginia, Charlottesville, VA 22908;

    Xemed LLC, Durham,NH 03824;

    Xemed LLC, Durham,NH 03824;

    Xemed LLC, Durham,NH 03824,Department of Physics, University of New Hampshire, Durham, NH 03824;

    Center for In Vivo Hyperpolarized Gas MR Imaging, Department of Radiology, University of Virginia, Charlottesville, VA 22908;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    gas exchange; pulmonary function; pulmonary ventilation;

    机译：气体交换;肺功能;肺通气;

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