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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >β-Catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching
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β-Catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching

机译：毛囊的真皮乳头中的β-连环蛋白活性调节色素类型的转换

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摘要

The switch between black and yellow pigment is mediated by the interaction between Melanocortin receptor 1 (Mc1r) and its antagonist Agouti, but the genetic and developmental mechanisms that modify this interaction to obtain different coat color in distinct environments are poorly understood. Here, the role of Wnt/β-catenin signaling in the regulation of pigment-type switching was studied. Loss and gain of function of β-catenin in the dermal papilla (DP) of the hair follicle results in yellow and black animals, respectively. β-Catenin activity in the DP suppresses Agouti expression and activates Corin, a negative regulator of Agouti activity. In addition, β-catenin activity in the DP regulates melanocyte activity by a mechanism that is independent of both Agouti and Corin. The coordinate and inverse regulation of Agouti and Corin renders pelage pigmentation sensitive to changes in β-catenin activity in the DP that do not alter pelage structure. As a result, the signals that specify two biologically distinct quantitative traits are partially uncoupled despite their common regulation by the β-catenin pathway in the same cells.
机译：黑色和黄色颜料之间的转换是由Melanocortin受体1（Mc1r）与它的拮抗剂Agouti之间的相互作用介导的，但对这种相互作用进行修饰以在不同环境中获得不同涂层颜色的遗传和发育机制了解甚少。在这里，研究了Wnt /β-catenin信号在调节颜料类型转换中的作用。 β-catenin在毛囊的真皮乳头（DP）中丧失和获得功能分别导致黄色和黑色动物。 DP中的β-连环蛋白活性抑制Agouti表达并激活Corin，Agin是Agouti活性的负调节剂。此外，DP中的β-catenin活性通过独立于Agouti和Corin的机制调节黑素细胞活性。 Agouti和Corin的配位和逆向调节作用使pelage色素沉着对DP中β-catenin活性的变化敏感，而不会改变pelage的结构。结果，尽管指定了两个生物学上不同的数量性状的信号在相同的细胞中受到β-catenin途径的共同调节，但仍部分解除了耦合。

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  • 作者

    David Enshell-Seijffers; Catherine Lindon; Eleanor Wu; Makoto M. Taketo; Bruce A. Morgan;

  • 作者单位

    Cutaneous Biology Research Center, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129;

    Cutaneous Biology Research Center, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129;

    Cutaneous Biology Research Center, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129;

    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo, Kyoto 606-8501, Japan;

    Cutaneous Biology Research Center, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    pheomelanin; eumelanin;

    机译：苯丙氨酸;

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