Double-strand breaks enhanced in nucleosome DNA lesions

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Double-strand breaks enhanced in nucleosome DNA lesions

机译：核小体DNA损伤中双链断裂增强

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Previous studies have shown that DNA damage in the form of apurin-ic/apyrimidinic (AP) sites occurs in most cells more than 10,000 times per day. Despite their ubiquity, AP sites are highly mutagenic and cytotoxic if not repaired. Jonathan Sczepanski et al.

机译：先前的研究表明，每天大多数细胞中以无嘌呤/ apyrimidinic（AP）位点形式出现的DNA损伤发生超过10,000次。尽管无处不在，但如果不修复，AP位点具有高度的诱变性和细胞毒性。 Jonathan Sczepanski等。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2010年第52期|p.22362|共1页
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Mechanical evolution of DNA double-strand breaks in the nucleosome [J] . Fabrizio Cleri, Fabio Landuzzi, Ralf Blossey PLoS Computational Biology . 2018,第6期

机译：核小体中DNA双链断裂的机械进化
2. Nucleosomes Suppress the Formation of Double-strand DNA Breaks during Attempted Base Excision Repair of Clustered Oxidative Damages [J] . Wendy Cannan, Betty P. Tsang, Susan S. Wallace, The Journal of biological chemistry . 2014,第29期

机译：核体抑制了在集群氧化损伤的尝试基础切除修复期间双链DNA断裂的形成
3. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions [J] . Cristini Agnese, Park Joon-Hyung, Capranico Giovanni, Nucleic Acids Research . 2016,第3期

机译：DNA-PK触发组蛋白泛素化和信号转导，响应转录阻滞拓扑异构酶I损伤修复过程中产生的DNA双链断裂
4. Double-strand breaks on a genomic DNA caused by ultrasound: Evaluation by single DNA observation [C] . Kenmotmsu Takahiro, Ogawa Naoki, Kubota Rinko, International Symposium on Micro-NanoMechatronics and Human Science . 2013

机译：超声引起的基因组DNA双链断裂：单DNA观察评估
5. Studies on the response to DNA double-strand breaks: Damage-dependent phosphorylations and DNA end resection. [D] . Peterson, Shaun Eric. 2009

机译：对DNA双链断裂反应的研究：损伤依赖性磷酸化和DNA末端切除。
6. Probing Enhanced Double-Strand Break Formation at Abasic Sites within Clustered Lesions in Nucleosome Core Particles [O] . Samya Banerjee, Supratim Chakraborty, Marco Paolo Jacinto, -1

机译：探测增强的双链断裂形成在核小体核心颗粒的聚集病变内的基础位点。
7. Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1 [O] . Guillaume Gaullier, Genevieve Roberts, Uma M. Muthurajan, 2019

机译：PARP2的核心近端DNA双链突破的桥接增强了其与HPF1的相互作用
8. DNA Ligase I is an In Vivo Substrate of DNA-Dependent Protein Kinase and is Activated by Phosphorylation in Response to DNA Double-Strand Breaks [R] . Bhat, K. R. , Benton, B. J. , Ray, R. 2006

机译：DNa连接酶I是DNa依赖性蛋白激酶的体内底物，并通过磷酸化活化以响应DNa双链断裂

Double-strand breaks enhanced in nucleosome DNA lesions

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