...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutrition
【24h】

Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutrition

机译：人类寿命的演变和衰老疾病：感染，炎症和营养的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Humans have evolved much longer lifespans than the great apes, which rarely exceed 50 years. Since 1800, lifespans have doubled again, largely due to improvements in environment, food, and medicine that minimized mortality at earlier ages, infections cause most mortality in wild chimpanzees and in traditional forager-farmers with limited access to modern medicine. Although we know little of the diseases of aging under premodern conditions, in captivity, chimpanzees present a lower incidence of cancer, ischemic heart disease, and neurodegeneration than current human populations. These major differences in pathology of aging are discussed in terms of genes that mediate infection, inflammation, and nutrition. Apolipoprotein E alleles are proposed as a prototype of pleiotropic genes, which influence immune responses, arterial and Alzheimer's disease, and brain development.
机译：人类进化出的寿命比大猩猩长得多，大猩猩很少超过50年。自1800年以来，寿命再次翻了一番，这主要是由于环境，食物和药物的改善，使早期年龄的死亡率降到了最低，感染导致野生黑猩猩和传统觅食农民的死亡率最高，而现代医学的获取却有限。尽管我们对近现代条件下的衰老疾病知之甚少，但在人工饲养下，黑猩猩的癌症，局部缺血性心脏病和神经退行性疾病的发病率要低于当前人群。在介导感染，炎症和营养的基因方面讨论了衰老病理学的这些主要差异。载脂蛋白E等位基因被提议作为多效基因的原型，其影响免疫反应，动脉和阿尔茨海默氏病以及大脑发育。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号