...
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Transcriptome-guided Characterization Of Genomic Rearrangements In A Breast Cancer Cell Line
【24h】

Transcriptome-guided Characterization Of Genomic Rearrangements In A Breast Cancer Cell Line

机译:转录组指导的乳腺癌细胞系中基因组重排的表征

获取原文
获取原文并翻译 | 示例
           

摘要

We have identified new genomic alterations in the breast cancer cell line HCC1954, using high-throughput transcriptome sequencing. With 120 Mb of cDNA sequences, we were able to identify genomic rearrangement events leading to fusions or truncations of genes including MRE11 and NSD1, genes already implicated in oncogenesis, and 7 rearrangements involving other additional genes. This approach demonstrates that high-throughput transcriptome sequencing is an effective strategy for the characterization of genomic rearrangements in cancers.
机译:我们已经确定了使用高通量转录组测序的乳腺癌细胞HCC1954中的新基因组改变。有了120 Mb的cDNA序列,我们能够鉴定出导致MRE11和NSD1等基因(已经牵涉到肿瘤发生的基因)和7种涉及其他其他基因的重排融合或截断的基因组重排事件。这种方法表明,高通量转录组测序是表征癌症基因组重排的有效策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号