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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Polymorphisms In Cd1d Affect Antigen Presentation And The Activation Of Cd 1d-restricted T Cells
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Polymorphisms In Cd1d Affect Antigen Presentation And The Activation Of Cd 1d-restricted T Cells

机译:Cd1d多态性影响抗原呈递和Cd 1d限制性T细胞的活化

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摘要

CD1 proteins constitute a distinct lineage of antigen-presenting molecules specialized for the presentation of lipid antigens to T cells. In contrast to the extensive sequence polymorphism characteristic of classical MHC molecules, CD1 proteins exhibit limited sequence diversity. Here, we describe the identification and characterization of CD1d alleles in wild-derived mouse strains. We demonstrate that polymorphisms in CD1d affect the presentation of endogenous and exogenous ligands to CD1d-restricted T cells, including type Ⅰ (Vα14i) and type Ⅱ (non-Vα14i) natural killer T (NKT) cells. Using congenic mice, we found CD1d polymorphisms affect the thymic selection of type Ⅰ NKT cells and induce allogeneic T cell responses. Collectively, results from these studies demonstrate a role for polymorphisms in influencing the development and function of CD1d-restricted T cells.
机译:CD1蛋白构成专门用于将脂质抗原呈递给T细胞的抗原呈递分子的独特谱系。与经典MHC分子的广泛序列多态性特征相反,CD1蛋白显示出有限的序列多样性。在这里,我们描述了野生小鼠品系中CD1d等位基因的鉴定和表征。我们证明,CD1d中的多态性影响内源性和外源性配体对CD1d限制性T细胞的呈递,包括Ⅰ型(Vα14i)和Ⅱ型(非Vα14i)自然杀伤性T(NKT)细胞。使用同系小鼠,我们发现CD1d多态性影响Ⅰ型NKT细胞的胸腺选择并诱导同种异体T细胞反应。总的来说,这些研究的结果证明了多态性在影响CD1d限制性T细胞的发育和功能中的作用。

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  • 作者单位

    Departments of Pathology, University of Chicago, Chicago, IL 60637 Department of Microbiology and Immunology, Northwestern University, Chicago, IL 60611;

    Departments of Pathology, University of Chicago, Chicago, IL 60637;

    Departments of Pathology, University of Chicago, Chicago, IL 60637;

    Departments of Pathology, University of Chicago, Chicago, IL 60637;

    Departments of Pathology, University of Chicago, Chicago, IL 60637;

    Departments of Pathology, University of Chicago, Chicago, IL 60637 Departments of Medicine, University of Chicago, Chicago, IL 60637;

    Departments of Pathology, University of Chicago, Chicago, IL 60637 Departments of Medicine, University of Chicago, Chicago, IL 60637;

    Departments of Medicine, University of Chicago, Chicago, IL 60637;

    Departments of Medicine, University of Chicago, Chicago, IL 60637;

    Departments of Pathology, University of Chicago, Chicago, IL 60637 Departments of Medicine, University of Chicago, Chicago, IL 60637;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    t cell activation; tcell development;

    机译:t细胞活化;t细胞发育;

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