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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Antibodies And Antigens: It's All About The Numbers Game
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Antibodies And Antigens: It's All About The Numbers Game

机译：抗体和抗原：一切与数字游戏有关

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摘要

Antibodies are exquisitely specific molecules that recognize and eliminate harmful agents bearing foreign pathogenic and disease antigens. Today, close to 100 therapeutic antibodies are in clinical trials and hundreds more in preclinical development. They are being used for treating a range of illnesses including inflammation, autoimmune diseases, cancer, cardiovascular diseases, allergic disorders, and infectious diseases. The focus of the antibody field has now essentially shifted from discovery to product development and, indeed, this area represents a triumph for the biotechnology industry. However, the selection of antibodies can be a laborious process, because this is normally done one antigen at a time. The article by Bowley et al. (1) in a recent issue of PNAS is pioneering and demonstrates how to accelerate the identification of antibodies to a multitude of antigens.
机译：抗体是识别和消除带有外来病原和疾病抗原的有害物质的特异分子。如今，近100种治疗性抗体正在临床试验中，数百种正在临床前开发中。它们被用于治疗多种疾病，包括炎症，自身免疫性疾病，癌症，心血管疾病，过敏性疾病和传染性疾病。抗体领域的重点现已从发现转向产品开发，实际上，这一领域代表了生物技术行业的胜利。但是，抗体的选择可能是一个费力的过程，因为通常一次只能完成一个抗原。 Bowley等人的文章。 （1）在PNAS的最新一期中是开创性的，并演示了如何加速鉴定多种抗原的抗体。

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