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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Perforin-mediated suppression of B-cell lymphoma
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Perforin-mediated suppression of B-cell lymphoma

机译：穿孔素介导的B细胞淋巴瘤抑制

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摘要

In the present study, we have examined the effect of perforin (pfp) deficiency in 4 models of mouse B-cell lymphomagenesis. We have examined pfp loss on the background of either Mlh1 tumor suppressor allele loss or oncogene expression;Ig heavy chain (Eμ)-v-Abl, Eμ-myc, and vav-bcl2]. Pfp was shown to act as a suppressor of B-cell malignancies characteristically driven by v-Abi or bcl-2, whereas Mlh loss cooperated in accelerating spontaneous B-cell lymphomas characteristic of pfp loss. No protective role for pfp was observed in the more aggressive Eμ-myc model of B-cell lymphoma. These transgenic models have allowed us to distinguish the role of pfp in surveillance of B-cell lymphomagenesis, as opposed to its loss simply driving the onset of a spontaneous lymphoma characteristic of pfp deficiency.
机译：在本研究中，我们检查了穿孔素（pfp）缺乏症在4种小鼠B细胞淋巴瘤形成模型中的作用。我们已经在Mlh1肿瘤抑制等位基因缺失或癌基因表达的背景下检测了pfp缺失； Ig重链（Eμ）-v-Abl，Eμ-myc和vav-bcl2]。 Pfp被证明可作为特征在于v-Abi或bcl-2驱动的B细胞恶性肿瘤的抑制物，而Mlh丢失可促进pfp丢失特征性的自发性B细胞淋巴瘤。在更具侵略性的B细胞淋巴瘤Eμ-myc模型中未观察到pfp的保护作用。这些转基因模型使我们能够区分pfp在监视B细胞淋巴瘤的过程中的作用，与之相反，其丢失仅驱动pfp缺乏症自发性淋巴瘤的发作。

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    Paul Bolitho; Shayna E. A. Street; Jennifer A. Westwood; Winfried Edelmann; Duncan MacGregor; Paul Waring; William K. Murray; Dale I. Godfrey; Joseph A. Trapani; Ricky W. Johnstone; Mark J. Smyth;

  • 作者单位

    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia;

    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia;

    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia;

    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461;

    Department of Anatomical Pathology, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia Department of Pathology, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia;

    Pathology and Diagnostics, Genentech Incorporated, South San Francisco, CA 94080;

    Department of Pathology, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia;

    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia;

    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Department of Pathology, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia;

    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Department of Pathology, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia;

    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Department of Pathology, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    tumor surveillance; lymphomagenesis; transgenic mice;

    机译：肿瘤监测;淋巴瘤转基因小鼠;

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