...
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Localization of a bacterial cytoplasmic receptor is dynamic and changes with cell-cell contacts
【24h】

Localization of a bacterial cytoplasmic receptor is dynamic and changes with cell-cell contacts

机译:细菌胞质受体的定位是动态的,并随着细胞接触而变化

获取原文
获取原文并翻译 | 示例
           

摘要

Directional motility in the gliding bacterium Myxococcus xanthus requires controlled cell reversals mediated by the Frz chemosen-sory system. FrzCD, a cytoplasmic chemoreceptor, does not form membrane-bound polar clusters typical for most bacteria, but rather cytoplasmic clusters that appear helically arranged and span the cell length. The distribution of FrzCD in living cells was found to be dynamic: FrzCD was localized in clusters that continuously changed their size, number, and position. The number of FrzCD clusters was correlated with cellular reversal frequency: fewer clusters were observed in hypo-reversing mutants and additional clusters were observed in hyper-reversing mutants. When moving cells made side-to-side contacts, FrzCD clusters in adjacent cells showed transient alignments. These events were frequently followed by one of the interacting cells reversing. These observations suggest that FrzCD detects signals from a cell contact-sensitive signaling system and then re-localizes as it directs reversals to distributed motility engines.
机译:滑翔细菌黄曲霉中的定向运动需要Frz化学信息系统介导的受控细胞逆转。 FrzCD是一种细胞质化学感受器,它不会形成大多数细菌所特有的膜结合性极性簇,而是形成螺旋状排列并跨越细胞长度的胞质簇。发现FrzCD在活细胞中的分布是动态的:FrzCD定位在不断改变其大小,数量和位置的簇中。 FrzCD簇的数目与细胞逆转频率相关:在低逆转突变体中观察到较少的簇,而在高逆转突变体中观察到其他簇。当移动单元进行左右接触时,相邻单元中的FrzCD簇显示出瞬时排列。这些事件之后经常是相互作用的细胞之一逆转。这些观察结果表明,FrzCD会检测到来自细胞接触敏感信号系统的信号,然后在将反向定向到分布式运动引擎时重新定位。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号