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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Recombination at DNA replication fork barriers is not universal and is differentially regulated by Swi1
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Recombination at DNA replication fork barriers is not universal and is differentially regulated by Swi1

机译：DNA复制叉壁垒的重组不是普遍的，并且受Swi1的差异调节

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摘要

DNA replication stress has been implicated in the etiology of genetic diseases, including cancers. It has been proposed that genomic sites that inhibit or slow DNA replication fork progression possess recombination hotspot activity and can form potential fragile sites. Here we used the fission yeast, Schizosaccharomyces pombe, to demonstrate that hotspot activity is not a universal feature of replication fork barriers (RFBs), and we propose that most sites within the genome that form RFBs do not have recombination hotspot activity under nonstressed conditions. We further demonstrate that Swi1, the TIMELESS homologue, differentially controls the recombination potential of RFBs, switching between being a suppressor and an activator of recombination in a site-specific fashion.
机译：DNA复制压​​力与遗传疾病（包括癌症）的病因有关。已经提出抑制或减慢DNA复制叉进展的基因组位点具有重组热点活性并且可以形成潜在的易碎位点。在这里，我们使用裂殖酵母粟酒裂殖酵母（Schizosaccharomyces pombe）来证明热点活性不是复制叉屏障（RFB）的普遍特征，并且我们提出了形成RFB的基因组中的大多数位点在非胁迫条件下都没有重组热点活性。我们进一步证明了Swi1（无时限的同源物）差异控制RFB的重组潜能，以位点特异性的方式在重组的抑制剂和活化剂之间进行切换。

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  • 作者

    David W. Pryce; Soshila Ramayah; Alessa Jaendling; Ramsay J. McFarlane;

  • 作者单位

    North West Cancer Research Fund Institute, School of Biological Sciences, College of Natural Sciences, Bangor University, Bangor, Gwynedd, LL57 2UW, United Kingdom;

    North West Cancer Research Fund Institute, School of Biological Sciences, College of Natural Sciences, Bangor University, Bangor, Gwynedd, LL57 2UW, United Kingdom;

    North West Cancer Research Fund Institute, School of Biological Sciences, College of Natural Sciences, Bangor University, Bangor, Gwynedd, LL57 2UW, United Kingdom;

    North West Cancer Research Fund Institute, School of Biological Sciences, College of Natural Sciences, Bangor University, Bangor, Gwynedd, LL57 2UW, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    fission yeast; genome stability; TIMELESS;

    机译：裂变酵母基因组稳定性永恒的;

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