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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Electrophysiological Correlates Of Default-mode Processing In Macaque Posterior Cingulate Cortex
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Electrophysiological Correlates Of Default-mode Processing In Macaque Posterior Cingulate Cortex

机译：猕猴后扣带回皮层中默认模式处理的电生理相关性

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摘要

During the course of daily activity, our level of engagement with the world varies on a moment-to-moment basis. Although these fluctuations in vigilance have critical consequences for our thoughts and actions, almost nothing is known about the neuronal substrates governing such dynamic variations in task engagement. We investigated the hypothesis that the posterior cingulate cortex (CGp), a region linked to default-mode processing by hemodynamic and metabolic measures, controls such variations. We recorded the activity of single neurons in CGp in 2 macaque monkeys performing simple tasks in which their behavior varied from vigilant to inattentive. We found that firing rates were reliably suppressed during task performance and returned to a higher resting baseline between trials. Importantly, higher firing rates predicted errors and slow behavioral responses, and were also observed during cued rest periods when monkeys were temporarily liberated from exteroceptive vigilance. These patterns of activity were not observed in the lateral intrapa-rietal area, an area linked to the frontoparietal attention network. Our findings provide physiological confirmation that CGp mediates exteroceptive vigilance and are consistent with the idea that CGp is part of the "default network" of brain areas associated with control of task engagement.rndefault network; lateral intraparietal cortex; working memory; task engagement; attention
机译：在日常活动过程中，我们与世界互动的程度会瞬间有所变化。尽管警惕性的这些波动会对我们的思想和行动产生重大影响，但是对于控制这种任务参与中的动态变化的神经元基质几乎一无所知。我们调查了后扣带回皮质（CGp）（通过血液动力学和代谢措施与默认模式处理相关联的区域）控制此类变化的假说。我们记录了两只执行简单任务的猕猴的CGp中单个神经元的活动，这些猴子的行为从警惕到不专心。我们发现，在执行任务期间，发射率得到了可靠的抑制，并且在两次试验之间恢复了较高的静止基线。重要的是，较高的开火率可预测错误和较慢的行为反应，并且在提示性休息期间（猴子暂时从外部警惕性警觉中解放出来）也可以观察到。这些活动模式未在pa外侧区域（与额顶额注网络相连的区域）中观察到。我们的发现提供了生理学上的证实，即CGp介导了警觉性警觉，并且与CGp是与任务参与控制相关的大脑区域“默认网络”的一部分的想法相一致。顶外侧皮层工作记忆；任务参与；注意

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    Benjamin Y. Hayden; David V. Smith; Michael L. Platt;

  • 作者单位

    Department of Neurobiology, Center for Neuroeconomic Studies, Center for Cognitive Neuroscience, Duke University School of Medicine, Durham, NC 27710;

    Department of Neurobiology, Center for Neuroeconomic Studies, Center for Cognitive Neuroscience, Duke University School of Medicine, Durham, NC 27710;

    Department of Neurobiology, Center for Neuroeconomic Studies, Center for Cognitive Neuroscience, Duke University School of Medicine, Durham, NC 27710 Department of Evolutionary Anthropology, Duke University, Durham, NC 27710;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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