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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Profile of Clifford Tabin
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Profile of Clifford Tabin

机译：Clifford Tabin的个人资料

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摘要

From the outside, the human body is a study in symmetry. But not everything is symmetrical inside. The heart, a baroque lump of muscle and plumbing, sits on the left side of the body. The stomach is lopsided. The intestines are a snarl of counterclockwise coils. But the embryo begins as a small sphere of identical cells. How does this broken symmetry develop?rnClifford (Cliff) Tabin, who was elected to the National Academy of Sciences in 2007, has spent significant effort during the course of his career working on that question. In 1995, he and colleagues found the first clue: they identified a molecular cascade that determines asymmetry in the vertebrate embryo (1). One of 3 key genes in this cascade, they reported, was Sonic hedgehog, which encodes a "morphogen" that diffuses across the embryo. The concentration of Sonic hedgehog determines how other molecules cooperate to build organs and limbs. Since its discovery by a collaboration between Tabin and 2 other labs, Sonic hedgehog has been widely implicated in human development.
机译：从外部看，人体是对对称性的研究。但并非所有事物都是对称的。心脏是巴洛克式的肌肉和管道肿块，位于身体的左侧。胃不平衡。肠子是一阵逆时针的线圈。但是胚胎开始时是一个由相同细胞组成的小球。克利福德·塔宾（Cliff）Tabin于2007年当选为美国国家科学院院士，在他的职业生涯中为解决这个问题付出了巨大的努力。在1995年，他和同事们发现了第一个线索：他们发现了一个决定脊椎动物胚胎不对称性的分子级联反应（1）。他们报告说，该级联反应中的三个关键基因之一是Sonic刺猬，它编码了一种“形态发生子”，它可以在整个胚胎中扩散。声波刺猬的浓度决定了其他分子如何协同构建器官和四肢。自从塔宾（Tabin）与其他2个实验室合作发现以来，音速刺猬已广泛参与人类发展。

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