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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator
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Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator

机译：通过将终产物与非典型应答调节剂结合来自动调节抗生素的生物合成

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摘要

In bacteria, many "atypical" response regulators (ARRs) lack the conserved residues important for phosphorylation by which typical response regulators switch their output response, suggesting the existence of alternative regulatory mechanisms. However, such mechanisms have not been established. JadR1, an OmpR-type ARR of Streptomycei venezuelae, appears to activate the transcription of jadomycin B (JdB) biosynthetic genes while repressing its own gene. JadR1 activities were inhibited in cells induced to produce JdB, which was found to bind directly to the N-terminal receiver domain of JadR1, causing JadR1 to dissociate from target promoters. The activity of a NarL-type ARR, RedZ, that regulates production of another antibiotic was likewise modulated by the end product (undecylprodigisines), implying that end-product-mediated control of antibiotic pathway-specific ARRs may be widespread. These results could prove relevant to knowledge-based improvements in yield of commercially important antibiotics.
机译：在细菌中，许多“非典型”反应调节剂（ARR）缺乏对磷酸化重要的保守残基，通过这些残基，典型的反应调节剂可切换其输出反应，表明存在其他调控机制。但是，尚未建立这样的机制。 JadR1是委内瑞斯链霉菌（Streptomycei venezuelae）的OmpR型ARR，它似乎在抑制其自身基因的同时激活了贾德霉素B（JdB）生物合成基因的转录。 JadR1活性在诱导产生JdB的细胞中受到抑制，而JdB被发现直接与JadR1的N末端受体域结合，从而导致JadR1从靶标启动子上解离。调节另一种抗生素产生的NarL型ARR RedZ的活性同样受终产物（十一烷基谷丙二胺）的调节，这意味着终产物介导的对抗生素途径特异性ARR的控制可能是广泛的。这些结果可能证明与商业上重要的抗生素产量的基于知识的提高有关。

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  • 作者

    Linqi Wang; Xiuyun Tian; Juan Wang; Haihua Yang; Keqiang Fan; Gangming Xu; Keqian Yang; Huarong Tan;

  • 作者单位

    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China;

    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China;

    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China;

    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China;

    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China;

    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China;

    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China;

    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    JadR1; ligand;

    机译：JadR1;配体;

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