首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution
【24h】

Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution

机译:粟酒裂殖酵母RNA聚合酶II,分辨率为3.6-A

获取原文
获取原文并翻译 | 示例
           

摘要

The second structure of a eukaryotic RNA polymerase II so far determined, that of the enzyme from the fission yeast Schizosac-charomyces pombe, is reported here. Comparison with the previous structure of the enzyme from the budding yeast Saccharomy-ces cerevisiae reveals differences in regions implicated in start site selection and transcription factor interaction. These aspects of the transcription mechanism differ between S. pombe and S. cerevisiae, but are conserved between S. pombe and humans. Amino acid changes apparently responsible for the structural differences are also conserved between S. pombe and humans, suggesting that the S. pombe structure may be a good surrogate for that of the human enzyme.
机译:在此报道了迄今为止确定的真核RNA聚合酶II的第二种结构,即裂变酵母裂殖酵母-酵母菌的酶的结构。与来自发芽酵母酿酒酵母的酶的先前结构的比较揭示了与起始位点选择和转录因子相互作用有关的区域的差异。转录机制的这些方面在粟酒裂殖酵母和酿酒酵母之间有所不同,但在粟酒裂殖酵母和人类之间是保守的。粟酒裂殖酵母和人类之间也明显保留了造成结构差异的氨基酸变化,这表明粟酒裂殖酵母的结构可能是人类酶结构的良好替代品。

著录项

  • 来源
  • 作者单位

    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 Department of Laboratory Medicine, Division of Metabolic Diseases, Karolinska Institutet, Novum, SE-141 86 Stockholm, Sweden;

    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 Department of Structural Biology, University of Pittsburgh Medical School, 1040 Biomedical Science Tower 3 (BST3), 3501 5th Avenue, Pittsburgh, PA 15260;

    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305;

    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    molecular replacement; x-ray crystallography; yeast;

    机译:分子置换X射线晶体学酵母;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号