...
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Environmental transmission of low pathogenicity avian influenza viruses and its implications for pathogen invasion
【24h】

Environmental transmission of low pathogenicity avian influenza viruses and its implications for pathogen invasion

机译:低致病性禽流感病毒的环境传播及其对病原体入侵的影响

获取原文
获取原文并翻译 | 示例
           

摘要

Understanding the transmission dynamics and persistence of avian influenza viruses (AIVs) in the wild is an important scientific and public health challenge because this system represents both a reservoir for recombination and a source of novel, potentially human-pathogenic strains. The current paradigm locates all important transmission events on the nearly direct fecal/oral bird-to-bird pathway. In this article, on the basis of overlooked evidence, we propose that an environmental virus reservoir gives rise to indirect transmission. This transmission mode could play an important epi-demiological role. Using a stochastic model, we demonstrate how neglecting environmentally generated transmission chains could underestimate the explosiveness and duration of AIV epidemics. We showthe important pathogen invasion implications of this phenomenon: the nonnegligible probability of outbreak even when direct transmission is absent, the long-term inf ectivity of locations of prior outbreaks, and the role of environmental heterogeneity in risk.
机译:了解禽流感病毒(AIV)在野外的传播动态和持久性是一项重要的科学和公共卫生挑战,因为该系统既是重组的储存库,又是新型的,可能是人致病性菌株的来源。当前的范例将所有重要的传播事件定位在几乎直接的粪便/口腔鸟类与鸟类之间的传播途径上。在本文中,基于被忽视的证据,我们提出环境病毒库可以间接传播。这种传播方式可能起重要的流行病学作用。使用随机模型,我们证明了忽略环境产生的传播链会如何低估AIV流行病的爆发性和持续时间。我们展示了此现象的重要病原体入侵含义:即使没有直接传播,也无法忽略爆发的可能性,先前爆发地点的长期传染性以及环境异质性在风险中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号