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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Decoupling of the brain's default mode network during deep sleep
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Decoupling of the brain's default mode network during deep sleep

机译:深度睡眠期间大脑默认模式网络的解耦

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摘要

The recent discovery of a circuit of brain regions that is highly active in the absence of overt behavior has led to a quest for revealing the possible function of this so-called default-mode network (DMN). A very recent study, finding similarities in awake humans and anesthetized primates, has suggested that DMN activity might not simply reflect ongoing conscious mentation but rather a more general form of network dynamics typical of complex systems. Here, by performing functional MRI in humans, it is shown that a natural, sleep-induced reduction of consciousness is reflected in altered correlation between DMN network components, most notably a reduced involvement of frontal cortex. This suggests that DMN may play an important role in the sustenance of conscious awareness.
机译:最近发现的没有明显行为的高度活跃的大脑区域电路导致人们寻求揭示这种所谓的默认模式网络(DMN)的可能功能。一项非常新的研究发现,在清醒的人类和麻醉的灵长类动物中存在相似之处,这表明DMN的活动可能不仅反映了持续的意识状态,而且反映了复杂系统中典型的网络动力学的更一般形式。在这里,通过在人类中进行功能性MRI,结果表明,DMN网络组件之间相关性的改变(最显着的是额叶皮层的减少)反映了睡眠引起的自然意识的自然降低。这表明DMN可能在维持意识中起重要作用。

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  • 作者单位

    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 Advanced MRI, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892;

    Language Section, Voice, Speech and Language Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892;

    Naval Medical Research Center, Silver Spring, MD 20910;

    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910;

    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910;

    Advanced MRI, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892;

    Advanced MRI, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    EEG; fMRI; resting state; connectivity; consciousness;

    机译:脑电图;功能磁共振成像;静止状态连接性;意识;

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