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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Persistence of fear memory across time requires the basolateral amygdala complex
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Persistence of fear memory across time requires the basolateral amygdala complex

机译:持续存在恐惧记忆需要基底外侧杏仁核复合体

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摘要

Mammals evolved a potent fear-motivated defensive system capable of single-trial fear learning that shows no forgetting over the lifespan of the animal. The basolateral amygdala complex (BLA) is considered an essential component of this conditional fear learning system. However, recent studies challenge this view and suggest that plasticity within other brain regions (i.e., central nucleus of the amygdala) may be crucial for fear conditioning. In the present study, we examine the mnemonic limits of contextual fear conditioning in the absence of the BLA using overtraining and by measuring remote fear memories. After excitotoxic lesions of the BLA were created, animals underwent overtraining and were tested at recent and remote memory intervals. Here we show that animals with BLA lesions can learn normal levels of fear. However, this fear memory loses its adaptive features: it is acquired slowly and shows substantial forgetting when remote memory is tested. Collectively, these findings suggest that fear-related plasticity acquired by brain regions outside of the BLA, unlike those acquired in the intact animals, do so for a relatively time-limited period.
机译:哺乳动物进化出了一种有效的,以恐惧为动机的防御系统,能够进行一次单次恐惧学习,在整个动物的寿命中都不会忘记。基底外侧杏仁核复合体(BLA)被认为是该条件恐惧学习系统的重要组成部分。但是,最近的研究挑战了这种观点,并暗示其他大脑区域(即杏仁核的中央核)内的可塑性对于恐惧调节至关重要。在本研究中,我们使用过度训练和通过测量远程恐惧记忆来检查在没有BLA的情况下情境恐惧条件的记忆极限。在产生BLA的兴奋毒性损伤后,对动物进行了过度训练,并在近期和远距离记忆时间间隔对其进行了测试。在这里,我们显示患有BLA病变的动物可以学习正常的恐惧水平。但是,这种恐惧存储器失去了其自适应功能:它被缓慢地获取,并且在测试远程存储器时显示出大量的遗忘。总体而言,这些发现表明,与完整动物不同,与BLA以外的大脑区域获得的与恐惧相关的可塑性在相对有限的时间内达到了。

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