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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Targeting an antimicrobial effector function in insect immunity as a pest control strategy
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Targeting an antimicrobial effector function in insect immunity as a pest control strategy

机译：以昆虫免疫力中的抗微生物效应子作为害虫控制策略

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摘要

Insect pests such as termites cause damages to crops and man-made structures estimated at over $30 billion per year, imposing a global challenge for the human economy. Here, we report a strategy for compromising insect immunity that might lead to the development of nontoxic, sustainable pest control methods. Gram-negative bacteria binding proteins (GNBPs) are critical for sensing pathogenic infection and triggering effector responses. We report that termite GNBP-2 (tGNBP-2) shows β(1,3)-glucanase effector activity previously unknown in animal immunity and is a pleiotro-pic pattern recognition receptor and an antimicrobial effector protein. Termites incorporate this protein into the nest building material, where it functions as a nest-embedded sensor that cleaves and releases pathogenic components, priming termites for improved antimicrobial defense. By means of rational design, we present an inexpensive, nontoxic small molecule glycomimetic that blocks tGNBP-2, thus exposing termites in vivo to accelerated infection and death from specific and opportunistic pathogens. Such a molecule, introduced into building materials and agricultural methods, could protect valuable assets from insect pests.
机译：白蚁等昆虫害虫每年对农作物和人造结构造成的破坏估计超过300亿美元，对人类经济构成了全球性挑战。在这里，我们报告了一种损害昆虫免疫力的策略，这可能会导致开发无毒，可持续的害虫控制方法。革兰氏阴性细菌结合蛋白（GNBP）对于感测病原体感染和触发效应反应至关重要。我们报告说，白蚁GNBP-2（tGNBP-2）显示出以前在动物免疫中未知的β（1,3）-葡聚糖酶效应子活性，并且是一种多效型模式识别受体和一种抗菌效应蛋白。白蚁将这种蛋白质整合到筑巢材料中，在白蚁中起巢状传感器的作用，裂解并释放病原体成分​​，引发白蚁以增强抗菌素的防御能力。通过合理的设计，我们提出了一种廉价的，无毒的小分子糖模拟物，该药物可阻断tGNBP-2，从而使白蚁在体内暴露于特定的和机会性病原体引起的加速感染和死亡。引入建筑材料和农业方法的这种分子可以保护有价值的资产免受虫害的侵害。

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  • 作者

    Mark S. Bulmer; Ido Bachelet; Rahul Raman; Rebeca B. Rosengaus; Ram Sasisekharan;

  • 作者单位

    Department of Biology, Northeastern University, Boston, MA 02115 Department of Biological Sciences, Towson University, Towson, MD 21252;

    Harvard-MIT Division of Health Sciences and Technology, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

    Harvard-MIT Division of Health Sciences and Technology, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

    Department of Biology, Northeastern University, Boston, MA 02115;

    Harvard-MIT Division of Health Sciences and Technology, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    β(1,3)-glucanase; Gram-negative bacteria binding proteins pattern recognition receptor; termites; social insect immunity;

    机译：β（1,3）-葡聚糖酶;革兰氏阴性细菌结合蛋白模式识别受体;白蚁社会昆虫免疫力;

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