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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >TRPA channels distinguish gravity sensing from hearing in Johnston's organ
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TRPA channels distinguish gravity sensing from hearing in Johnston's organ

机译：TRPA通道将重力感应与约翰斯顿器官的听觉区分开

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摘要

Although many animal species sense gravity for spatial orientation, the molecular bases remain uncertain. Therefore, we studied Drosophila melanogaster, which possess an inherent upward movement against gravity-negative geotaxis. Negative geotaxis requires Johnston's organ, a mechanosensory structure located in the antenna that also detects near-field sound. Because channels of the transient receptor potential (TRP) superfamily can contribute to mechanosensory signaling, we asked whether they are important for negative geotaxis. We identified distinct expression patterns for 5 TRP genes; the TRPV genes nanchung and inactive were present in most Johnston's organ neurons, the TRPN gene nompC and the TRPA gene pain ess were localized to 2 subpopulations of neurons, and the TRPA gane pyrexia was expressed in cap cells that may interact with the neurons. Likewise, mutating specific TRP genes produced distinct phenotypes, disrupting negative geotaxis {painless and pyrexia), hearing (nompc), or both (nanchung and inactive). Our genetic, physiological and behavioral data indicate that the sensory component of negative geotaxis involves multiple TRP genes. The results also distinguish between different mechanosensory modalities and set the stage for understanding how TRP channels contribute to mechanosensation.
机译：尽管许多动物都感觉到重力的空间定向性，但分子基础仍然不确定。因此，我们研究了果蝇黑腹果蝇（Drosophila melanogaster），它具有抵抗重力负地心的固有向上运动。负趋向性需要约翰斯顿氏器官，这是一种位于天线中的机械感官结构，还可以检测近场声音。由于瞬时受体电位（TRP）超家族的通道可以促进机械感觉信号传导，因此我们询问它们是否对负大地趋向重要。我们确定了5种TRP基因的不同表达模式；在大多数约翰斯顿的器官神经元中存在TRPV基因nanchung和非活性，TRPN基因nompC和TRPA基因疼痛位于两个神经元亚群中，并且TRPA甘氨酸发热在可能与神经元相互作用的帽细胞中表达。同样，突变特定的TRP基因会产生不同的表型，破坏负地轴性（无痛和发热），听力（nompc）或两者（南充和非活跃）。我们的遗传，生理和行为数据表明，负大地定向的感觉成分涉及多个TRP基因。结果还区分了不同的机械感觉模态，并为理解TRP通道如何促进机械感觉奠定了基础。

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  • 作者

    Yishan Sun; Lei Liu; Yehuda Ben-Shahar; Julie S. Jacobs; Daniel F. Eberl; Michael J. Welsh;

  • 作者单位

    Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242 Department of Internal Medicine, University of Iowa, Iowa City, IA 52242;

    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242;

    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242;

    Department of Biology, University of Iowa, Iowa City, IA 52242;

    Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242 Department of Biology, University of Iowa, Iowa City, IA 52242;

    Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242 Department of Internal Medicine, University of Iowa, Iowa City, IA 52242 Howard Hughes Medical Institute,University of Iowa, Iowa City, IA 52242 Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    drosophila; transient receptor potential; geotaxis;

    机译：果蝇瞬时受体电位地趋;

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