...
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
【24h】

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

机译:IL-1家族成员和STAT激活剂诱导Th2,Th17和Th1细胞产生细胞因子

获取原文
获取原文并翻译 | 示例
           

摘要

Expression of T1ST2, the IL-33R, by Th2 cells requires GATA3. Resting Th2 cells express little GATA3, which is increased by IL-33 and a STAT5 activator, in turn increasing T1ST2 from its low-level expression on resting Th2 cells. Th2 cells that have upregulated T1ST2 produce IL-13, but not IL-4, in response to IL-33 plus a STAT5 activator in an antigen-independent, NF-κB-dependent, cyclo-sporin A (CsA)-resistant manner. Similarly, Th17 cells produce IL-17A in response to IL-1β and a STAT3 activator and Th1 cells produce IFNγ in response to IL-18 and a STAT4 inducer. Thus, each effector Th cell produces cytokines without antigenic stimulation in response to an IL-1 family member and a specific STAT activator, implying an innate mechanism through which memory CD4 T cells are recruited by an induced cytokine environment.
机译:Th2细胞表达T1ST2(IL-33R)需要GATA3。静止的Th2细胞表达的GATA3很少,IL-33和STAT5激活剂会增加GATA3的表达,从而使T1ST2从在静止的Th2细胞上的低水平表达开始增加。 T1ST2上调的Th2细胞以抗原非依赖性,NF-κB依赖性,环孢菌素A(CsA)耐药的方式响应IL-33和STAT5活化剂产生IL-13,但不产生IL-4。类似地,Th17细胞响应IL-1β和STAT3激活物产生IL-17A,Th1细胞响应IL-18和STAT4诱导物产生IFNγ。因此,每个效应Th细胞产生对IL-1家族成员和特异性STAT活化剂无抗原刺激的细胞因子,这暗示了诱导的细胞因子环境通过其募集记忆CD4T细胞的先天机制。

著录项

  • 来源
  • 作者单位

    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;

    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;

    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;

    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;

    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    IL-33; TSLP; IL-18; STAT5; T1ST2;

    机译:IL-33;TSLP;18日STAT5;T1ST2;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号