...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Human vulnerability to stress depends on amygdala's predisposition and hippocampal plasticity
【24h】

Human vulnerability to stress depends on amygdala's predisposition and hippocampal plasticity

机译：人对压力的脆弱性取决于杏仁核的易感性和海马可塑性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Variations in people's vulnerability to stressful life events may rise from a predated neural sensitivity as well as from differential neural modifications in response to the event. Because the occurrence of a stressful life event cannot be foreseen, characterizing the temporal trajectory of its neural manifestations in humans has been a real challenge. The current prospective study examined the emotional experience and brain responses of 50 a priori healthy new recruits to the Israeli Defense Forces at 2 time points: before they entered their mandatory military service and after their subsequent exposure to stressful events while deployed in combat units. Over time, soldiers reported on increase in stress symptoms that was correlated with greater amygdala and hippocampus responsiveness to stress-related content. However, these closely situated core limbic regions exhibited different temporal trajectories with regard to the stress effect; whereas amygdala's reactivity before stress predicted the increase in stress symptoms, the hippocampal change in activation over time correlated with the increase in such symptoms. Hippocampal plasticity was also reflected by a modification over time of its functional coupling with the ventromedial prefrontal cortex, and this coupling magnitude was again predicted by predated amygdala reactivity. Together, these findings suggest that variations in human's likelihood to develop symptomatic phenomena following stressful life events may depend on a balanced interplay between their amygdala's predisposing reactivity and hippocampal posteriori intra- and interregional plasticity. Accordingly, an individually tailored therapeutic approach for trauma survivors should target these 2 neural probes while considering their unique temporal prints.
机译：人们对压力性生活事件的脆弱性的变化可能源于预先确定的神经敏感性以及对事件做出反应的不同神经修饰。由于无法预料到应激性生活事件的发生，因此表征其在人类中的神经表现的时间轨迹一直是一个真正的挑战。当前的一项前瞻性研究在两个时间点检查了50名先验健康的新兵对以色列国防军的情感体验和大脑反应：在两个时间点：他们进入义务兵役制之前以及随后在部署到作战部队中时承受压力事件之后。随着时间的流逝，士兵们报告说压力症状增加，这与杏仁核和海马体对压力相关内容的反应性增强有关。然而，就应力作用而言，这些紧密分布的核心边缘区表现出不同的时间轨迹。而杏仁核在应激前的反应性预示了应激症状的增加，而海马激活随时间的变化与此类症状的增加相关。海马的可塑性也通过其与腹侧前额叶皮层的功能性耦合作用随时间的变化而反映出来，并且这种耦合程度再次由早先的杏仁核反应性预测。总之，这些发现表明，在压力大的生活事件之后，人类出现症状现象的可能性的变化可能取决于杏仁核的易感反应性与海马后区内部和区域间可塑性之间的平衡相互作用。因此，针对创伤幸存者的个性化治疗方法应针对这两种神经探针，同时考虑其独特的颞印。

著录项

  • 来源
  • 作者

    Roee Admon; Gad Lubin; Orit Stern; Keren Rosenberg; Lee Sela; Haim Ben-Ami; Talma Hendler;

  • 作者单位

    Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Witzman 6, 46239 Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, P.O. Box 39040, 69978 Tel Aviv, Israel;

    Mental Health Department, Medical Corps, Israeli Defense Forces, Military P.O. Box 02149, Tel Aviv, Israel;

    Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Witzman 6, 46239 Tel Aviv, Israel;

    Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Witzman 6, 46239 Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, P.O. Box 39040, 69978 Tel Aviv, Israel;

    Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Witzman 6, 46239 Tel Aviv, Israel Weizmann Institute for Science, Rehovot, Israel;

    Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Witzman 6, 46239 Tel Aviv, Israel;

    Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Witzman 6, 46239 Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, P.O. Box 39040, 69978 Tel Aviv, Israel Department of Psychology, Tel Aviv University, P.O. Box 39040, 69978 Tel Aviv, Israel;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    individual differences; prospective study; fMRI; trauma;

    机译：个体差异;前瞻性研究;功能磁共振成像;外伤;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号