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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Variation in the μ-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection
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Variation in the μ-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection

机译：μ阿片受体基因（OPRM1）的变异与对社交排斥的倾向和神经敏感性有关

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Scientific understanding of social pain-the hurt feelings resulting from social rejection, separation, or loss-has been facilitated by the hypothesis that such feelings arise, in part, from some of the same neural and neurochemical systems that generate the unpleasant feelings resulting from physical pain. Accordingly, in animals, the painkiller morphine not only alleviates the distress of physical pain, but also the distress of social separation. Because morphine acts on the μ-opioid receptor, we examined whether variation in the μ-opioid receptor gene (OPRM1), as measured by the functional A118G polymorphism, was associated with individual differences in rejection sensitivity. Participants (n = 122) completed a self-report inventory of dispositional sensitivity to social rejection and a subsample (n = 31) completed a functional MRI session in which they were rejected from an online ball-tossing game played with two supposed others. The A118G polymorphism was associated with dispositional sensitivity to rejection in the entire sample and in the fMRI subsample. Consistent with these results, G allele carriers showed greater reactivity to social rejection in neural regions previously shown to be involved in processing social pain as well as the unpleasantness of physical pain, particularly the dorsal anterior cingulate cortex (dACC) and anterior insula. Furthermore, dACC activity mediated the relationship between the A118G polymorphism and dispositional sensitivity to rejection, suggesting that this is a critical site for μ-opioid-related influence on social pain. Taken together, these data suggest that the A118G polymorphism specifically, and the μ-opioid receptor more generally, are involved in social pain in addition to physical pain.
机译：对社会痛苦的科学理解-社会排斥，分离或损失导致的伤害感觉-的假设促进了这样的假设，即这种感觉部分是由某些相同的神经和神经化学系统产生的，这些系统会产生由身体造成的不愉快的感觉痛。因此，在动物中，止痛药吗啡不仅减轻了身体疼痛的困扰，而且减轻了社会分离的困扰。因为吗啡作用于μ阿片受体，所以我们检查了通过功能性A118G多态性测量的μ阿片受体基因（OPRM1）的变异是否与排斥敏感性的个体差异相关。参与者（n = 122）完成了关于社交排斥倾向性的自我报告清单，子样本（n = 31）完成了功能性MRI环节，其中他们与其他两个假想的在线掷球游戏无关。 A118G多态性与整个样本和fMRI子样本中排斥反应的处置敏感性相关。与这些结果一致，G等位基因携带者在先前显示参与处理社会疼痛以及身体疼痛（特别是背扣带前皮质（dACC）和前岛鞘）的神经区域中表现出对社交排斥的更高反应性。此外，dACC活性介导了A118G多态性与排斥反应的敏感性之间的关系，表明这是μ阿片类药物相关影响社会痛苦的关键部位。综上所述，这些数据表明，除了身体上的疼痛外，A118G多态性和更广泛的μ阿片受体还参与了社交疼痛。

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