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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Human-specific evolution of sialic acid targets: Explaining the malignant malaria mystery?
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Human-specific evolution of sialic acid targets: Explaining the malignant malaria mystery?

机译:唾液酸靶标的人特异性进化:解释恶性疟疾的奥秘吗?

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摘要

Malaria caused by Plasmo-dium falciparum ("malignant malaria") is one of the most devastating pathogens of humans (1). Plasmodium reichenowi, which infects chimpanzees and gorillas, is the closest relative of P. falciparum (2). In early 20th-century experiments (never to be replicated), blood from P. reichenowi-infected chimpanzees was injected into humans, but failed to produce infections (3).
机译:恶性疟原虫(“恶性疟疾”)引起的疟疾是人类最具破坏力的病原体之一(1)。感染黑猩猩和大猩猩的赖氏疟原虫是恶性疟原虫的近亲(2)。在20世纪初期的实验中(从未复制),将感染雷氏疟原虫的黑猩猩的血液注入人体内,但未产生感染(3)。

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  • 作者

    Ajit Varki; Pascal Gagneux;

  • 作者单位

    Center for Academic Research and Training in Anthropogeny, University of California at San Diego, La Jolla, CA 92093-0687 Glycobiology Research and Training Center, and Departments of University of California at San Diego, La Jolla, CA 92093-0687 Medicine and University of California at San Diego, La Jolla, CA 92093-0687 Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-0687;

    Center for Academic Research and Training in Anthropogeny, University of California at San Diego, La Jolla, CA 92093-0687 Glycobiology Research and Training Center, and Departments of University of California at San Diego, La Jolla, CA 92093-0687 Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-0687;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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