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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Generation of pluripotent stem cells from patients with type 1 diabetes
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Generation of pluripotent stem cells from patients with type 1 diabetes

机译：从1型糖尿病患者中产生多能干细胞

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摘要

Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic β cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would be useful for disease modeling. We show here that induced pluripotent stem (iPS) cells can be generated from patients with T1D by reprogramming their adult fibroblasts with three transcription factors (OCT4, SOX2, KLF4). T1D-specific iPS cells, termed DiPS cells, have the hallmarks of pluripotency and can be differentiated into insulin-producing cells. These results are a step toward using DiPS cells in T1D disease modeling, as well as for cell replacement therapy.
机译：1型糖尿病（T1D）是胰腺β细胞自身免疫破坏的结果。导致疾病的细胞和分子缺陷仍然未知。由T1D患者产生的多能细胞可用于疾病建模。我们在这里显示可以通过用三种转录因子（OCT4，SOX2，KLF4）对成年成纤维细胞进行重编程，从T1D患者中产生诱导性多能干（iPS）细胞。 T1D特异性iPS细胞（称为DiPS细胞）具有多能性的特征，可以分化为产生胰岛素的细胞。这些结果是迈向在T1D疾病建模以及细胞替代治疗中使用DiPS细胞的一步。

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  • 作者

    Rene Maehr; Shuibing Chen; Melinda Snitow; Thomas Ludwig; Lisa Yagasaki; Robin Goland; Rudolph L. Leibel; Douglas A. Melton;

  • 作者单位

    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138;

    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138;

    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138;

    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032;

    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138;

    Division of Molecular Genetics and Naomi Barrie Diabetes Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032;

    Division of Molecular Genetics and Naomi Barrie Diabetes Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032;

    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    β cell; disease model; autoimmune; directed differentiation; endoderm;

    机译：β细胞;疾病模型自身免疫定向分化内胚层;

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