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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Secretin as a neurohypophysial factor regulating body water homeostasis
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Secretin as a neurohypophysial factor regulating body water homeostasis

机译：分泌素作为调节机体水稳态的神经垂体因子

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摘要

Hypothalamic magnocellular neurons express either one of the neurohypophysial hormones, vasopressin or oxytocin, along with different neuropeptides or neuromodulators. Axonal terminals of these neurons are generally accepted to release solely the two hormones but not others into the circulation. Here, we show that secretin, originally isolated from upper intestinal mucosal extract, is present throughout the hypothalamo-neurohypophysial axis and that it is released from the posterior pituitary under plasma hyperosmolality conditions. In the hypothalamus, it stimulates vasopressin expression and release. Considering these findings together with our previous findings that show a direct effect of secretin on renal water reab-sorption, we propose here that secretin works at multiple levels in the hypothalamus, pituitary, and kidney to regulate water homeostasis. Findings presented here challenge previous understanding regarding the neurohypophysis and could provide new concepts in treating disorders related to osmoregulation.
机译：下丘脑的巨细胞神经元表达神经下垂体激素，加压素或催产素之一，以及不同的神经肽或神经调节剂。这些神经元的轴突末端通常被认为仅将两种激素释放出来，而不释放其他激素进入循环系统。在这里，我们显示最初从上层肠粘膜提取物中分离出来的促胰液素存在于整个下丘脑-神经下垂体轴，并且在血浆高渗性条件下从垂体后叶释放。在下丘脑中，它刺激血管加压素的表达和释放。考虑到这些发现以及我们先前的发现，表明分泌素对肾脏水的再吸收具有直接作用，我们在此提出，分泌素在下丘脑，垂体和肾脏中以多种水平起作用，以调节水的体内稳态。此处提出的发现挑战了有关神经垂体的先前理解，并可能为治疗与渗透调节有关的疾病提供新的概念。

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    Jessica Y. S. Chu; Leo T. O. Lee; C. H. Lai; H. Vaudry; Y. S. Chan; W. H. Yung; Billy K. C. Chow;

  • 作者单位

    School of Biological Sciences, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong, China;

    School of Biological Sciences, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong, China;

    Department of Physiology and Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong, China;

    lnstitut National de la Sante et de la Recherche Medicale Unite 413, Laboratory of Cellular and Molecular Neuroendocrinology, University of Rouen, 76821 Mont-Saint-Aignan, France;

    Department of Physiology and Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong, China;

    Department of Physiology, Chinese University of Hong Kong, Hong Kong, China;

    School of Biological Sciences, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    hypothalamic-pituitary axis; osmoregulation; vasopressin;

    机译：下丘脑-垂体轴;渗透压血管加压素;

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