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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >aPKCλ/ι promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6
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aPKCλ/ι promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6

机译：aPKCλ/ι通过白介素6的转录激活以自分泌方式促进前列腺癌细胞的生长

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摘要

Understanding the mechanism by which hormone refractory prostate cancer (HRPC) develops remains a major issue. Alterations in HRPC include androgen receptor (AR) changes. In addition, the AR is activated by cytokines such as interleukin-6 (IL-6). Atypical protein kinase C (aPKCλ/ι) has been implicated in the progression of several cancers. Herein, we provide evidence that aPKCλ/ι expression correlates with prostate cancer recurrence. Experiments in vitro and in vivo revealed aPKCλ/ι to be involved in prostate cancer cell growth through secretion of IL-6. Further, aPKCλ/ι activates transcription of the IL-6 gene through NFkB and AP-1. We conclude that aPKCλ/ι promotes the growth of hormone independent prostate cancer cells by stimulating IL-6 production in an autocrine manner. Our findings not only explain the link between aPKCλ/ι and IL-6, implicated in the progression a variety of cancers, but also establish a molecular change involved in the development of HRPC. Further, aPKCλ/ι expression might be a biomarker for prostate cancer progression.
机译：了解激素难治性前列腺癌（HRPC）发生的机制仍然是一个主要问题。 HRPC的变化包括雄激素受体（AR）的变化。另外，AR被白细胞介素6（IL-6）等细胞因子激活。非典型蛋白激酶C（aPKCλ/ i）与几种癌症的进展有关。在本文中，我们提供了aPKCλ/ i表达与前列腺癌复发相关的证据。体外和体内实验表明，aPKCλ/ i通过分泌IL-6参与前列腺癌细胞的生长。此外，aPKCλ/ i通过NFkB和AP-1激活IL-6基因的转录。我们得出结论，aPKCλ/ i通过以自分泌方式刺激IL-6的产生来促进激素非依赖性前列腺癌细胞的生长。我们的发现不仅解释了aPKCλ/ l与IL-6之间的联系，涉及多种癌症的进展，而且还建立了涉及HRPC发生的分子变化。此外，aPKCλ/ i表达可能是前列腺癌进展的生物标志。

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    Hitoshi lshiguro; Kazunori Akimoto; Yoji Nagashima; Yasuyuki Kojima; Takeshi Sasaki; Yukari lshiguro-lmagawa; Noboru Nakaigawa; Shigeo Ohno; Yoshinobu Kubota; Hiroji Uemura;

  • 作者单位

    Departments of Urology, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, JapanrnPhotocatalyst Group, Kanagawa Academy of Science and Technology. 3-2-1, Sakado, Takatsu-ku, Kawasaki, Kanagawa 213-0012, Japan;

    Molecular Biology, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan;

    Molecular Pathology, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, JapanrnAdvanced Medical Research Center, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan;

    Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan;

    Division of Pathology, Yokohama City University Medical Center, 4-57, Urafune-cho, Minami-ku Yokohama, Kanagawa 232-0024, Japan;

    Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan;

    Departments of Urology, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan;

    Molecular Biology, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan Advanced Medical Research Center, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan;

    Departments of Urology, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan Advanced Medical Research Center, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan;

    Departments of Urology, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    IL-6; PSA; recurrence;

    机译：IL-6;PSA;复发;

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