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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Performance level modulates adult age differences in brain activation during spatial working memory
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Performance level modulates adult age differences in brain activation during spatial working memory

机译：性能水平调节空间工作记忆过程中成年人大脑激活的年龄差异

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摘要

Working memory (WM) shows pronounced age-related decline. Functional magnetic resonance imaging (fMRI) studies have revealed age differences in task-related brain activation. Evidence based primarily on episodic memory studies suggests that brain activation patterns can be modulated by task difficulty in both younger and older adults. In most fMRI aging studies on WM, however, performance level has not been considered, so that age differences in activation patterns are confounded with age differences in performance level. Here, we address this issue by comparing younger and older low and high performers in an event-related fMRI study. Thirty younger (20-30 years) and 30 older (60-70 years) healthy adults were tested with a spatial WM task with three load levels. A region-of-interest analysis revealed marked differences in the activation patterns between high and low performers in both age groups. Critically, among the older adults, a more "youth-like" load-dependent modulation of the blood oxygen level-dependent signal was associated with higher levels of spatial WM performance. These findings underscore the need of taking performance level into account when studying changes in functional brain activation patterns from early to late adulthood.
机译：工作记忆（WM）显示出明显的与年龄相关的下降。功能磁共振成像（fMRI）研究显示与任务相关的大脑激活存在年龄差异。主要基于情景记忆研究的证据表明，无论年龄大小，成年人均可通过任务难度来调节大脑的激活模式。但是，在大多数针对WM的fMRI衰老研究中，并未考虑性能水平，因此激活模式的年龄差异与性能水平的年龄差异是混杂的。在这里，我们通过在事件相关的功能磁共振成像研究中比较年轻和年长的低表现者和高表现者来解决这个问题。对30名年轻（20-30岁）和30名年龄较大（60-70岁）的健康成年人进行了空间WM任务，测试了三种负荷水平。感兴趣的区域分析显示，两个年龄段的高绩效者和低绩效者之间的激活模式存在明显差异。至关重要的是，在老年人中，血氧水平依赖性信号的更“像年轻人一样”的负荷依赖性调制与更高水平的空间WM性能相关。这些发现强调了研究成年早期至晚期的功能性大脑激活模式变化时需要考虑性能水平的需求。

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  • 作者

    Irene E. Nagel; Claudia Preuschhof; Shu-Chen Li; Lars Nyberg; Lars Baeckman; Ulman Lindenberger; Hauke R. Heekeren;

  • 作者单位

    Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany;

    Department of Education and Psychology, Freie Universitat Berlin, 14195 Berlin, Germany;

    Max Planck Institute for Human Development, 14195 Berlin, Germany;

    Department of Integrative Medical Biology and Radiation Sciences, Umea University, SE-901 87 Umea, Sweden;

    Max Planck Institute for Human Development, 14195 Berlin, Germany Aging Research Centre, Karolinska Institute, SE-171 77 Stockholm, Sweden;

    Max Planck Institute for Human Development, 14195 Berlin, Germany;

    Max Planck Institute for Human Development, 14195 Berlin, Germany Department of Education and Psychology, Freie Universitat Berlin, 14195 Berlin, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    aging; fMRI; premotor cortex; performance load;

    机译：老化;功能磁共振成像;运动前皮层性能负荷;

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