...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The microbial mimic poly IC induces durable and protective CD4~+ T cell immunity together with a dendritic cell targeted vaccine
【24h】

The microbial mimic poly IC induces durable and protective CD4~+ T cell immunity together with a dendritic cell targeted vaccine

机译：微生物模拟多克隆IC与树突状细胞靶向疫苗一起诱导持久性和保护性CD4〜+ T细胞免疫

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

CD4~+ Th1 type immunity is implicated in resistance to global infectious diseases. To improve the efficacy of T cell immunity induced by human immunodeficiency virus (HIV) vaccines, we are developing a protein-based approach that directly harnesses the function of dendritic cells (DCs) in intact lymphoid tissues. Vaccine proteins are selectively delivered to DCs by antibodies to DEC-205/ CD205, a receptor for antigen presentation. We find that polyri-boinosinicpolyribocytidylic acid (poly IC) independently serves as an adjuvant to allow a DC-targeted protein to induce protective CD4~+ T cell responses at a mucosal surface, the airway. After two doses of DEC-targeted, HIV gag p24 along with poly IC, responder CD4~+ T cells have qualitative features that have been correlated with protective function. The T cells simultaneously make IFN-y, tumor necrosis factor (TNF)-α, and IL-2, and in high amounts for prolonged periods. The T cells also proliferate and continue to secrete IFN-γ in response to HIV gag p24. The adjuvant role of poly IC requires Toll-like receptor (TLR) 3 and melanoma differentiation-associated gene-5 (MDA5) receptors, but its analog poly IC_(12)U requires only TLR3. We suggest that poly IC be tested as an adjuvant with DC-targeted vaccines to induce numerous multifunctional CD4~+ Th1 cells with proliferative capacity.
机译：CD4〜+ Th1型免疫力与对全球传染病的抵抗力有关。为了提高由人类免疫缺陷病毒（HIV）疫苗诱导的T细胞免疫的功效，我们正在开发一种基于蛋白质的方法，该方法可直接利用完整淋巴组织中的树突状细胞（DC）的功能。疫苗蛋白通过DEC-205 / CD205（抗原呈递受体）的抗体选择性地递送至DC。我们发现，聚核糖核酸聚核糖酸（poly IC）独立地用作佐剂，以使靶向DC的蛋白质在粘膜表面气道诱导保护性CD4〜+ T细胞反应。经过两剂DEC靶向的HIV gag p24以及poly IC后，反应性CD4〜+ T细胞具有与保护功能相关的定性特征。 T细胞同时长期大量产生IFN-γ，肿瘤坏死因子（TNF）-α和IL-2。响应HIV gag p24，T细胞也增殖并继续分泌IFN-γ。 poly IC的辅助作用需要Toll样受体（TLR）3和黑色素瘤分化相关基因5（MDA5）受体，但其类似的poly IC_（12）U仅需要TLR3。我们建议将poly IC作为DC靶向疫苗的佐剂进行测试，以诱导具有增殖能力的众多多功能CD4〜+ Th1细胞。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号