Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene

Sue Mei Tan-Wong; Juliet D. French; Nicholas J. Proudfoot; Melissa A. Brown

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Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene

机译：哺乳动物BRCA1基因启动子和终止子区域之间的动态相互作用

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The 85-kb breast cancer-associated gene BRCA1 is an established tumor suppressor gene, but its regulation is poorly understood. We demonstrate by gene conformation analysis in both human cell lines and mouse mammary tissue that gene loops are imposed on B

机译：85 kb的乳腺癌相关基因BRCA1是已建立的抑癌基因，但对其调控知之甚少。通过人类细胞系和小鼠乳腺组织中的基因构象分析，我们证明了基因环被强加于B

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《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第13期|5160-5165|共6页
作者
Sue Mei Tan-Wong; Juliet D. French; Nicholas J. Proudfoot; Melissa A. Brown;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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关键词
transcriptional regulation; chromatin conformation; gene repression; mammary gland; breast cancer;

机译：转录调控;染色质构象基因抑制乳腺乳腺癌;

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机译：全基因组无浆质细胞AnkA-DNA相互作用在基因间区域和基因启动子中富集，并与感染诱导的差异基因表达相关
2. Detection of BRCA1/2 large genomic rearrangement including BRCA1 promoter-region deletions using next-generation sequencing [J] . Clinica chimica acta: International journal of clinical chemistry and applied molecular biology . 2020,第期

机译：检测BRCA1 / 2大型基因组重排，包括使用下一代测序缺失BRCA1启动子区缺失
3. Unusual insertion element polymorphisms in the promoter and terminator regions of the mucAB-like genes of R471a and R446b. [J] . Kulaeva OI, Koonin EV, Wootton JC, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1998,第2期

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6. Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene [O] . Sue Mei Tan-Wong, Juliet D. French, Nicholas J. Proudfoot, 2008

机译：哺乳动物BRCA1基因启动子和终止子区域之间的动态相互作用
7. Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene. [O] . Tan-Wong, SM, French, JD, Proudfoot, NJ, 2008

机译：哺乳动物BRCA1基因启动子和终止子区域之间的动态相互作用。
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Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene

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