The lattice as allosteric effector: Structural studies of αβ- and γ-tubulin clarify the role of GTP in microtubule assembly

Luke M. Rice; Elizabeth A. Montabana; David A. Agard

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The lattice as allosteric effector: Structural studies of αβ- and γ-tubulin clarify the role of GTP in microtubule assembly

机译：作为变构效应子的晶格：αβ-和γ-微管蛋白的结构研究阐明了GTP在微管组装中的作用

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摘要

GTP-dependent microtubule polymerization dynamics are required for cell division and are accompanied by domain rearrangements in the polymerizing subunit, αβ-tubulin. Two opposing models describe the role of GTP and its relationship to conf ormational cha

机译：GTP依赖的微管聚合动力学是细胞分裂所必需的，并伴随着聚合亚基αβ-微管蛋白的结构域重排。两种相反的模型描述了GTP的作用及其与配置对话的关系。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第14期|5378-5383|共6页
作者
Luke M. Rice; Elizabeth A. Montabana; David A. Agard;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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关键词
dynamic instability; microtubules;

机译：动态不稳定微管;

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1. Microtubule assembly governed by tubulin allosteric gain in flexibility and lattice induced fit [J] . Maxim Igaev, Helmut Grubmüller eLife journal . 2018,第january期

机译：微管组装受微管蛋白变构性控制的弹性和晶格诱导的适应
2. Microtubule assembly governed by tubulin allosteric gain in flexibility and lattice induced fit [J] . Maxim Igaev, Helmut Grubmüller eLife journal . 2018,第april期

机译：微管组装受微管蛋白变构性控制的弹性和晶格诱导的适应
3. A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics [J] . Elisabeth A Geyer, Alexander Burns, Beth A Lalonde, eLife journal . 2015,第april期

机译：突变使微管蛋白构象和GTPase循环解偶联，揭示了微管动力学的变构控制
4. Mathematical modeling of the microtubule dynamic instability: a new approch of GTP-tubulin hydrolysis [C] . Ayuna Barlukova, Stéphane Honoré, Florence Hubert Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology . 2016

机译：微管动态不稳定性的数学建模：GTP-小管蛋白水解的新方法
5. Functional differences of β-tubulin isotypes: A study of microtubule assembly and antimitotic drug resistance [D] . Yang, Hailing 2007

机译：β-微管蛋白同种型的功能差异：微管组装和抗有丝分裂药物耐药性的研究
6. The lattice as allosteric effector: Structural studies of αβ- and γ-tubulin clarify the role of GTP in microtubule assembly [O] . Luke M. Rice, Elizabeth A. Montabana, David A. Agard 2008

机译：作为变构效应子的晶格：αβ-和γ-微管蛋白的结构研究阐明了GTP在微管组装中的作用
7. The lattice as allosteric effector: Structural studies of αβ- and γ-tubulin clarify the role of GTP in microtubule assembly [O] . Rice, Luke M., Montabana, Elizabeth A., Agard, David A. 2008

机译：作为变构效应子的晶格：αβ-和γ-微管蛋白的结构研究阐明了GTP在微管组装中的作用

The lattice as allosteric effector: Structural studies of αβ- and γ-tubulin clarify the role of GTP in microtubule assembly

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