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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Impact of overactive bladder on the brain: Central sequelae of a visceral pathology
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Impact of overactive bladder on the brain: Central sequelae of a visceral pathology

机译：膀胱过度活动症对大脑的影响：内脏病理的中央后遗症

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Neural circuits that allow for reciprocal communication between the brain and viscera are critical for coordinating behavior with visceral activity. At the same time, these circuits are positioned to convey signals from pathologic events occurring in viscera to the brain, thereby providing a structural basis for comorbid central and peripheral symptoms. In the pons, Barrington's nucleus and the norepineph-rine (NE) nucleus, locus coeruleus (LC), are integral to a circuit that links the pelvic viscera with the forebrain and coordinates pelvic visceral activity with arousal and behavior. Here, we demonstrate that a prevalent bladder dysfunction, produced by partial obstruction in rat, has an enduring disruptive impact on cortical activity through this circuit. Within 2 weeks of partial bladder obstruction, the activity of LC neurons was tonically elevated. LC hyperactivity was associated with cortical electroencephalographic activation that was characterized by decreased low-frequency (1-3 Hz) activity and prominent theta oscillations (6-8 Hz) that persisted for 4 weeks. Selective lesion of the LC-NE system significantly attenuated the cortical effects. The findings underscore the potential for significant neurobehavioral consequences of bladder disorders, including hyperarousal, sleep disturbances, and disruption of sensorimotor integration, as a result of central noradrenergic hyperactivity. The results further imply that pharmacological manipulation of central NE function may alleviate central sequelae of these visceral disorders.
机译：允许大脑和内脏之间相互交流的神经回路对于协调行为与内脏活动至关重要。同时，这些电路的位置可以将内脏发生的病理事件的信号传递到大脑，从而为合并的中枢和外周症状提供结构基础。在脑桥中，Barrington核和去甲肾上腺素（NE）核，蓝斑轨迹（LC）是将盆腔内脏与前脑连接起来并协调盆腔内脏活动与觉醒和行为的回路必不可少的部分。在这里，我们证明了大鼠部分阻塞所引起的普遍的膀胱功能障碍，通过该电路对皮层活动具有持久的破坏性影响。在部分膀胱梗阻的2周内，LC神经元的活性呈色调升高。 LC多动症与皮质脑电图激活相关，其特征是低频（1-3 Hz）活动减少和持续4周的显着theta振荡（6-8 Hz）。 LC-NE系统的选择性病变明显减弱了皮层效应。这些发现强调了由于中枢去甲肾上腺素能亢进导致膀胱疾病的严重神经行为后果的可能性，包括过度兴奋，睡眠障碍和感觉运动整合破坏。该结果进一步暗示中枢NE功能的药理操作可以减轻这些内脏疾病的中枢后遗症。

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