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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Profile of Axel Brunser
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Profile of Axel Brunser

机译：Axel Brunser的个人资料

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Axel Brunger is so thoroughly interdisciplinary that it is hard to pin down exactly what kind of scientist he is. "Biophysicist" would be a start. He began his career as a computational theorist, but in 1998 he jumped into wet-lab molecular biology. Deeply involved in protein crystallography, he is expert not only in obtaining structures but also in exploring the biochemical behavior of large proteins or complexes, particularly those involved in transmitting impulses at neural synapses. But ask any structural biologist who Brunger is, and you will probably hear that he is the creator of X-PLOR and its successor, CNS. These popular software packages combine the fundamental methods of simulated annealing and cross-validation of x-ray diffraction and NMR data. Researchers use X-PLOR and CNS to produce refined, atomic-level structures that reveal the workings of enzymes and molecular machines.rnFor his own advances, and those he has enabled others to achieve, Brunger was inducted into the National Academy of Sciences in 2005. His Inaugural Article (1), published in the October 2, 2007 issue of PNAS, reports the structure of Ufd2p, a ubiquitin ligase that participates in the degradation of misfolded proteins at the endoplasmic reticulum. Axel Brunger was born Axel Brunger in 1956 in Leipzig, East Germany. (He dropped the umlaut when he became an American citizen in 1991.) His parents were both doctors, and even though they were making a living of sorts, they decided the regime was preventing them from advancing because they did not want to get involved in the Communist Party.
机译：阿克塞尔·布鲁格（Axel Brunger）如此跨学科，以至于很难确切地确定他是什么样的科学家。 “生物物理学家”将是一个开始。他以计算理论家的身份开始了他的职业生涯，但是在1998年，他跳入了湿实验室分子生物学领域。他深深地参与了蛋白质晶体学研究，不仅是获得结构的专家，而且还是探索大型蛋白质或复合物的生物化学行为的专家，尤其是那些在神经突触中传递脉冲的蛋白质或复合物。但是，请问任何一位布鲁格结构生物学家，您可能会听说他是X-PLOR及其继承者CNS的创造者。这些流行的软件包结合了模拟退火的基本方法以及X射线衍射和NMR数据的交叉验证。研究人员使用X-PLOR和CNS产生精制的原子级结构，揭示了酶和分子机器的作用。rn由于他自己的进步以及使他人得以实现的那些进步，Brunger于2005年被选入美国国家科学院他在2007年10月2日出版的PNAS上的就职论文（1）报告了Ufd2p的结构，Ufd2p是一种泛素连接酶，参与内质网错折叠蛋白的降解。 Axel Brunger于1956年在东德莱比锡出生。 （1991年成为美国公民时，他丢掉了变音。）他的父母都是医生，即使他们以某种方式谋生，他们还是认为政权阻止了他们前进，因为他们不想参与其中。共产党。

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